Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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TL;DR: The methanol extract of the flowers of Lagerstroemia parviflora Roxb was investigated for its effect on a cough model induced by sulphur dioxide gas in mice and it exhibited significant antitussive activity when compared with the control in a dose-dependent manner.
4 citations
Journal Article•
TL;DR: The antitussive effect of two different drugs A (Codeine, Phenyltoloxamine) and B (Dihydrocodeine, Remedacen) was compared in a double blind clinical trial by measuring the frequency and strength of cough attacks for 7 hours.
Abstract: The antitussive effect of two different drugs A (Codeine, Phenyltoloxamine) and B (Dihydrocodeine, Remedacen) was compared in a double blind clinical trial by measuring the frequency and strength of cough attacks for 7 hours. The cough attacks were measured by a pressure-monitoring device which was externally fastened to the throat. Drug B suppressed the strenght and frequency for at least 9 hours after application while the effectiveness of drug A lasted only for about 6 hours after application. In any case the respiratory drive was unaffected.
4 citations
TL;DR: This regulation of cough through sensory nerves of the Ad fibres or C-fibres, and through recently-discovered channels such as the acid-sensing ion channels (ASIC), transient receptor potential channels (TRP) such as TRPV1 and TRPA1, and some specific voltage-gated sodium channels are described in four reviews.
4 citations
TL;DR: It is suggested that moguisteine may have a therapeutical benefit in reducing the coughing associated with treatment with inhibitors of angiotensin-converting enzyme.
4 citations
Journal Article•
TL;DR: Isoaminile citrate was concluded to be an effective and relatively safe antitussive agent and did not require a decrease in dose or withdrawal of treatment in any of the patients.
Abstract: The efficacy and safety of a new centrally acting antitussive agent, isoaminile citrate, was compared with that of chlophedianol hydrochloride in a double-blind, randomized interpatient study. A total of 66 patients participated, two and four patients were lost to follow-up with isoaminile and chlophedianol, respectively. In the experimentally induced cough in 12 normal human subjects, isoaminile (40 mg) was as effective as chlophedianol (20 mg), but its duration of action was somewhat longer. One subject developed allergic skin rash with chlophedianol and was withdrawn from the study. In 60 patients with cough associated with chest diseases, isoaminile (40 mg, 3 x daily) was as effective as chlophedianol (20 mg, 3 x daily) in suppressing cough as judged from the 3-h and 24-h cough counts. The increase in PEFR at day 7 of treatment was somewhat more marked with chlophedianol as compared with isoaminile. None of the drugs interfered with the expectoration process. The side effects observed were few, mild in nature, and did not require a decrease in dose or withdrawal of treatment in any of the patients. Isoaminile citrate was concluded to be an effective and relatively safe antitussive agent. Isoaminile citrate, alpha(isopropyl)-alpha-(beta-dimethylaminoproyl) phenylacetonitrile citrate, is a centrally acting antitussive agent. In animal experiments this drug was as efficacious as codeine but was devoid of any respiratory depressant effect [Krause 1958, Kuroda et al. 1971]. This controlled double-randomized interpatient study was designed to test the comparative efficacy and safety of isoaminile and chlophedianol, another centrally acting antitussive, in humans.
4 citations