Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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3 citations
Journal Article•
TL;DR: Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dro Propane-1,2-diol, the racemate from which it is derived.
Abstract: The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which it is derived. The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate.
3 citations
TL;DR: The antitussive agents that show analgesic effect produce depression of respiration and possibly tolerance, while antihistaminic antitussives often lead to drowsiness, and the local anaesthetic ones usually have a high toxicity.
Abstract: MOST of the known antitussive agents also possess, in varying degree, other pharmacological properties, such as the analgesic, antihistaminic, local anaesthetic and spasmolytic ones (Silvestrini and Maffii1). These activities are often responsible for, or directly connected with, specific clinical side effects that may limit the effect. In particular, the antitussives that show analgesic effect produce depression of respiration and possibly tolerance, while antihistaminic antitussives often lead to drowsiness, and the local anaesthetic ones usually have a high toxicity.
3 citations
TL;DR: L-tryptophan can be considered to be a useful constituent of antitussive preparations and the liability with respect to physical dependence on dihydrocodeine was not enhanced by the simultaneous administration of L-t Kryptophan.
Abstract: The effects of L-tryptophan and the major constituents of cough medicines on the antitussive effect of dihydrocodeine were examined in a comparative study with anesthetized rats. The antitussive effect of dihydrocodeine was enhanced by simultaneous administration of noscapine or methylephedrine. In rats treated with noscapine and methylephedrine together, the effect of dihydrocodeine was more markedly enhanced. Furthermore, L-tryptophan reduced by half the antitussive ED50 (AtD50) of dihydrocodeine. There was no difference between the AtD50 of dihydrocodeine when administered in combination with noscapine and methylephedrine and that of dihydrocodeine when combined with noscapine and L-tryptophan. The AtD50 of noscapine and dextromethorphan was also reduced by about half when what was administered with L-tryptophan. By contrast, the liability with respect to physical dependence on dihydrocodeine was not enhanced by the simultaneous administration of L-tryptophan. These results suggest that L-tryptophan can be considered to be a useful constituent of antitussive preparations.
3 citations
3 citations