Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.

Pharmacological control of cough.

Abstract: Cough constitutes an important medical problem in all ages. Although treatment of underlying pathologies, e.g., bronchial asthma, upper respiratory tract infection, etc. is well justified to cure cough, non-specific therapy in the form of a number of antitussive agents like, codeine, dextromethorphan, etc. is widely practiced to suppress it. Most of these agents are efficacious and well-tolerated. Nevertheless, CNS toxicities may occur in new-borns, especially those with immature metabolic profile. Some recent reports about interactions (involving hepatic cytochrome P450 enzymes) between dextromethorphan and other drugs are also noteworthy.

Antitussive oral composition

Abstract: PURPOSE: To orally administer a tryptophan-contg. medicinal composition for antitussive therapy. CONSTITUTION: This composition, which contains tryptophan as active ingredient, is obtained by incorporating the active ingredient with pref. an antitussive agent for oral use (e.g. dextromethorphan (salt)) and also common medicinal support at one's discretion followed by pharmaceutical manufacturing by conventional means. In this case, the weight ratio of the tryptophan to antitussive agent is (2:1) to (5,000:1), and these two ingredients account for 5-95wt.% and 1-50wt.% of this composition for solid and liquid formulations, respectively. The solid formulations include tablets, capsules, granules, lozenges and bulk powders, while, the liquid formulations include solutions, suspensions, syrups and emulsions. The daily dose of this composition is 2.0-3,000mg/kg.

Cariogenic antitussive agents

Abstract: Nine cough mixtures available on the Swiss market and randomly chosen were tested telemetrically. With the exception of Sinecod all syrups effected immediate and long-lasting pH-depressions in interdental plaque. Patients should be informed on the pronounced caries-promoting potential of these medications.