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Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.


Papers
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Journal ArticleDOI
TL;DR: Results indicated an antitussive effect of Carum copticum which was even greater than that of codeine at concentrations used, and was not due to its main constituent, carvacrol.

58 citations

Journal ArticleDOI
TL;DR: This double-blind parallel group study compared the efficacy of two preparations, an antitussive or an antitUSSive-& sympathomimetic combination, with that of placebo in the treatment of cough related to acute respiratory infection in children.
Abstract: Although cough may be caused by several factors, the most common causes are acute viral respiratory infections (1). Cough related to viral infection is usually transient and needs no treatment. However, antitussive drugs are widely used in such situations despite of criticism (2, 3). In this double-blind parallel group study we compared the efficacy of two preparations, an antitussive or an antitussive-& sympathomimetic combination, with that of placebo in the treatment of cough related to acute respiratory infection in children.

56 citations

Journal ArticleDOI
TL;DR: Once‐daily administration of a relatively low dose of baclofen is sufficient to achieve significant cough inhibition, although at least 14 to 28 days of therapy may be required to attain maximal antitussive effect.
Abstract: Gamma-aminobutyric acid (GABA) is a central inhibitory neurotransmitter that also exists in the lungs. The GABA-agonist baclofen has been shown to have antitussive activity via a central mechanism in animals. Recently it was demonstrated that a 14-day course of baclofen given three times daily significantly inhibits the cough reflex in healthy volunteers. Because of the prolonged antitussive effect of baclofen that has been previously observed, the present study was conducted to evaluate the antitussive effect of low-dose, oral baclofen given once daily. Forty-one healthy volunteers were randomly assigned in a double-blind manner to receive a 28-day course of baclofen, either 10 mg or 20 mg once daily, or placebo. Subjects underwent cough challenge testing with inhaled capsaicin to establish baseline cough reflex sensitivity, and subsequently after 14 and 28 days of therapy. Subjects receiving baclofen 20 mg daily demonstrated significant inhibition of cough sensitivity after 14 days and after 28 days of therapy compared with baseline. Neither placebo nor baclofen 10 mg daily had a significant effect on cough sensitivity. No serious side effects were experienced by any study participant. These results confirm the recent observation that baclofen has significant antitussive activity in humans. Further, once-daily administration of a relatively low dose of baclofen is sufficient to achieve significant cough inhibition, although at least 14 to 28 days of therapy may be required to attain maximal antitussive effect. These results support further investigation of baclofen or other GABA-agonists as potential therapeutic agents for chronic, nonproductive cough.

56 citations

Journal ArticleDOI
TL;DR: Placebo-related decreases in urge-to-cough are accompanied by commensurate decreases in several brain regions activated during capsaicin inhalation, suggesting that beliefs about treatment can modify the central processing of inputs arising from the airways.
Abstract: Rationale: Antitussive therapies are accompanied by a substantial placebo effect, indicating that inhibitory circuits in the brain have a significant capacity to regulate cough neural processing. However, essentially nothing is known about the identity of these inhibitory circuits or how they reduce coughing. Understanding these processes may help develop more effective antitussive therapies in the future.Objectives: To identify regional changes in human brain activity related to the urge-to-cough after placebo antitussive administration.Methods: Seventeen healthy participants undertook functional magnetic resonance imaging while completing a series of inhalations of capsaicin to induce the urge-to-cough. The resultant brain responses associated with capsaicin inhalation without any treatment were compared with those induced by capsaicin after placebo antitussive administration.Measurements and Main Results: There was a significant decrease in participants’ ratings of urge-to-cough after the placebo antit...

55 citations

Patent
25 Apr 2003
TL;DR: A consumable film adapted to adhere to and dissolve in the oral cavity of a consumer comprising at least one water-soluble polymer, one antitussive agent, and a mucosa-coating effective amount of a coccoating agent is defined in this article.
Abstract: A consumable film adapted to adhere to and dissolve in the oral cavity of a consumer comprising at least one water soluble polymer, at least one antitussive agent and a mucosa-coating effective amount of a mucosa-coating agent.

54 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20211
20204
20185
20172
20165
20158