Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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TL;DR: The localization of the central cough mechanism was studied by electrically stimulating the lower brainstem in cats lightly anesthetizing with pentobarbital sodium or in unanesthetized midcollicular decerebrate preparations, suggesting that these agents act centrally to suppress the cough responses.
Abstract: The localization of the central cough mechanism was studied by electrically stimulating the lower brainstem in cats lightly anesthetized with pentobarbital sodium or in unanesthetized midcollicular decerebrate preparations. Cough responses were recorded with the aid of a microphone. The cough responsive region was concentrated in an area dorsomedial to the trigeminal tract and nucleus. The sites of action of antitussive agents (dextromethorphan, codeine, clonazepam, diazepam and caramiphen) were studied on the centrally induced cough responses. Each of these drugs was administered intravenously to determine the dorsal levels for cough suppression. In other series, the threshold dose via the intravertebral route was determined first. Because the agent necessary to prevent cough via this route was so small in amount, recovery usually occurred in 20 to 90 minutes. Then the same agent was given intravenously in an attempt to obtain an effective dose which was close to the minimum dose for blocking the cough. The mean effective doses of these agents to abolish the cough via the vertebral artery were only about 1/20 of those required via intravenous injection. The findings suggest that these agents act centrally to suppress the cough responses. Clonazepam was found to be the most potent antitussive among these agents, the mean effective dose being about 1/35 of that of codeine. The antitussive potency of benzodiazepines is not well correlated with their muscle relaxant activity. For instance, clonazepam and diazepam have the same potency in depressing polysynaptic spinal reflexes, whereas the former is 6 times more potent than diazepam as an antitussive. This finding indicates that clonazepam has a high specificity as an antitussive.
48 citations
TL;DR: The data suggest that U-50, 488H and U-62, 066E exert their antitussive effect on rats through stimulation of κ-opioid receptors, and the system that involves 5-HT1 receptors may be more important than theSystem that involves5-HT2 receptors.
45 citations
TL;DR: The methanol extract of the leaves of Passiflora incarnata exhibited significant antitussive activity on sulfur dioxide-induced cough in mice, the cough inhibition being comparable to that of codeine phosphate.
45 citations
TL;DR: Caffeoylquinic acids, astersaponins, and aster peptides, rather than shionone, may be the main constituents responsible for the expectorant and antitussive activities of A. tataricus and act in a synergistic way.
44 citations
43 citations