Showing papers on "Aphanamixis published in 2007"

Use of Aphanamixis polystacha extracts or fractions against 5-lipoxygenase mediated diseases

Abstract: The invention discloses 5 -lipoxygenase inhibitory product prepared from botanical sources. More specifically, the invention describes 5 -lipoxygenase inhibitory extracts or bio-enriched extracts or fractions of Aphanamixis polystachya, methods of making 5 -lipoxygenase inhibitory extract, and methods of treating and/or preventing disease conditions mediated by 5 -lipoxygenase by using the said extract. The invention further discloses pharmaceutical or nutraceutical or dietary compositions containing therapeutically effective amounts of the extracts of Aphanamixis polystachya in combination with other known anti-inflammatory agents useful for oral, parenteral and topical administration.

Short Communication Analgesic activity of the ethanolic extract of Aphanamixis polystachya bark

Abstract: SUMMARY Ethanolic extract of Aphanamixis polystachya bark was used to investigate its analgesic activity byacetic acid induced writhing in mice. The bark extract exhibited statistically significant and dosedependent analgesic activity in mice. The bark extract at the doses of 250 and 500 mg/kg bodyweight showed 40.69% and 62.07% writhing inhibition respectively in mice whereas diclofenac-Na produced 75.17% writhing inhibition as a positive control. Key words: Aphanamixis polystachya; Acetic acid induced writhing INTRODUCTION Aphanamixis polystachya (Meliaceae), commonlyknown as ‘Roina’, is a large timber tree withbunches of rounded locular fruits and glossy deepbrown seeds and widely distributed in India,China and Bangladesh (Ghani, 2003). Ethanolicextract of the stem possesses anti-cancer propertiesand that bark is an effective immunosuppressive,showed anti-tumours and abdominal complaints.Seed extract possesses antibacterial and antifungalproperties and also used as a liniment of rheumatism(Ghaini, 2003; Rabi and Gupta, 1995). A number ofchemical constituents have been reported in thisplant such as rohitukin, limonoids, amooranin,tetranotriterpene and aphanamixinin (Chatterjee etal., 1970; Mulholand and Naidoo, 1999; Ghani,2003; Rabi et al., 2003).As part of our on-going pharmacological screeningof randomly selected Bangladeshi medicinal plants(Uddin et al., 2004, 2005; Shilpi et al., 2005; Rouf etal., 2006, 2007 ), we now report on the investigationof analgesic activity of Aphanamixis polystachyabark extract.