Showing papers on "Aphanamixis published in 2010"
TL;DR: Five tirucallane type C(26) triterpenoids, accompanied by two known compounds, were isolated from the stem barks of Aphanamixis grandifolia and in vitro evaluated for their cytotoxic activities against five tumor cell lines.
39 citations
TL;DR: In this article, a cycloartane-type triterpenoid featuring an unusual skeleton of 31 carbon atoms, (17E)-cycloart-17,26-dien-3β-ol, and other two new compounds 4R-hydroxy-4-(9S-hydrox-12-methylhexan-6-yl)-3-methylcyclopent-2-enone (6) and 7-hydoxy-5-(2,5′-dimethoxyphenyl)-2-methoxy-6methyl-1,
Abstract: (23E)-25-Methylcycloart-23-en-3β-ol (1), a cycloartane-type triterpenoid featuring an unusual skeleton of 31 carbon atoms, (17E)-cycloart-17,26-dien-3β-ol (2), a new cycloartane-type triterpenoid, and the other two new compounds 4R-hydroxy-4-(9S-hydroxy-12-methylhexan-6-yl)-3-methylcyclopent-2-enone (6) and 7-hydroxy-5-(2′-hydroxy-4′,5′-dimethoxyphenyl)-2-methoxy-6-methyl-1,4-naphthoquinone (7), together with three known cycloart-3β-ol triterpenoids (3—5) were isolated from aerial parts of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analysis, and that of 1 was confirmed by single-crystal X-ray diffraction. The absolute configuration of two carbon stereocenters of compound 6 was determined to be 4R,9S by means of circular dichroism (CD) and auxiliary chiral α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) derivatives, respectively. The compound 3 exhibited significant cytotoxicities against HL-60, Hep G2 and HeLa, and compounds 1, 2, 5, 6 and 7 exhibited modest cytotoxicities. No activity of compound 4 could be due to the absence of the hydroxyl group at C-24.
23 citations