Showing papers on "Aphanamixis published in 2011"
TL;DR: Two new limonoids, namely aphanamolides A and B, were isolated from the seeds of Aphanamixis polystachya and featured an unprecedented carbon skeleton via the formation of a C-3-C-6 bond.
35 citations
TL;DR: Two new highly oxidized A,B-seco limonoids, aphapolynin A (1) and B (2), were isolated from the fruits of Aphanamixis polystachya and their structures were elucidated by spectroscopic analysis.
29 citations
TL;DR: Four novel nortriterpenoids, 24,25-epoxy-tirucall-7,20(E)-diene-3,23-dione, together with one known compound mombasol, were isolated from the stem barks of Aphanamixis grandifolia.
Abstract: Four novel nortriterpenoids, 24,25-epoxy-tirucall-7,20(E)-diene-3,23-dione (1), 24,25,26,27-tetranortirucall-1,7-diene-23(21)-lactone (2), 3α-hydroxy-tirucall-7-ene-20-one (3), and 3-oxo-tirucall-7-ene-3,20-dione (4), together with one known compound mombasol (5) were isolated from the stem barks of Aphanamixis grandifolia. Their structures were elucidated on the basis of various spectroscopic analysis including electrospray ionization (ESI)-MS, high resolution (HR)-ESI-MS, IR, 1D- and 2D-NMR techniques (heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY)), and by comparison of their spectral data with those reported. The absolute configuration of compound 1 was determined by circular dichroism (CD) exciton chirality.
20 citations
TL;DR: Two new acyclic diterpenes, melidianolic acids A and B, have been isolated from the bark of Aphanamixis grandifolia and showed antimalarial activity against Plasmodium falciparum 3D7.
Abstract: Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively.
12 citations
TL;DR: Seven new protolimonoids, named aphagranins A–G (1–7), along with four known compounds, were isolated from the ethanol extract of the stem barks of Aphanamixis grandifolia, achieving structure elucidation and signal assignments on the basis of spectral and chemical evidences.
Abstract: Seven new protolimonoids, named aphagranins A-G (1-7), along with four known compounds, were isolated from the ethanol extract of the stem barks of Aphanamixis grandifolia. Structure elucidation and signal assignments were achieved on the basis of spectral and chemical evidences.
11 citations
TL;DR: Phytochemical investigation on the stem bark of Aphanamixis grandifolia afforded five novel tirucallane‐type triterpenoids, which showed moderate activities against human MCF‐7 and HeLa cancer cells.
Abstract: Phytochemical investigation on the stem bark of Aphanamixis grandifolia afforded five novel tirucallane-type triterpenoids, (13α,14β,17α,23Z)-25-methoxy-21,23-epoxylanosta-7,20(22),23-triene-3,21-dione (1), (13α,14β,17α,23Z)-21,23-epoxylanosta-7,20(22),23,25-tetraene-3,21-dione (2), (3R,5R, 9R,10R,13S,14S,17S)-17-{(2R,3S,5R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-2,3,4,5-tetrahydro-2,5-dimethoxyfuran-3-yl}-4,4,10,13,14-pentamethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (3), (5R,9R,10R,13S,14S,17S)-17-{(2R,3S,5R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-2,5-dimethoxytetrahydrofuran-3-yl}-1,2,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-4,4,10,13,14-pentamethyl-3H-cyclopenta[a]phenanthren-3-one (4), and (3α,13α,14β,17α,20S,23R)-23-ethoxy-3-hydroxy-21,23-epoxylanost-7-en-24-one (5). The (1) H- and (13) C-NMR spectra of all compounds were fully assigned using a combination of 2D-NMR experiments, including HSQC, HMBC, and ROESY sequences. The structure of 1 with the absolute configuration was determined by ECD calculation. Compounds 3 and 4 showed moderate activities against human MCF-7 and HeLa cancer cells.
11 citations
TL;DR: In this article, cycloartane-type triterpenoids (I and II) and (II) were isolated along with two previously unknown compounds (III and IV).
Abstract: Two new cycloartane-type triterpenoids (I) and (II) are isolated along with two previously unknown compounds (III) and (IV).
3 citations
TL;DR: In this paper, four novel tircullane-type nortriterpenoids (I, II, III and IV) were isolated together with previously known mombasol and showed that they can be used together with other mombasols.
Abstract: Four novel tircullane-type nortriterpenoids (I)—(IV) are isolated together with previously known mombasol.