Showing papers on "Aphanamixis published in 2012"
TL;DR: The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera suggested it may be a potent defensive component of A. polystachya.
89 citations
TL;DR: Nine known triterpenoids were isolated from stems of Aphanamixis grandifolia Blume, and their structures were established by extensive spectroscopic and X-ray crystal diffraction studies.
19 citations
TL;DR: Two tirucallane C 27 -triterpenoid epimers, aphagranins A (1 ) and B (2 ), featuring an unprecedented enolized cyclopentenone presented in the side-chain at C-17, were isolated from the stem barks of Aphanamixis grandifolia.
15 citations
TL;DR: Aphanagranin A (1) possessed a rare four membered oxygen heterocyclic ring and its absolute configurations were determined on the basis of the signal crystal X-ray diffraction analysis.
Abstract: Four new limonoids, named aphanagranins AD (14), were isolated from the fruits of Aphanamixis grandifolia. The new structures were determined by spectroscopic methods especially 1D and 2D NMR analysis. Aphanagranin A (1) possessed a rare four membered oxygen heterocyclic ring and its absolute configurations were determined on the basis of the signal crystal X-ray diffraction analysis. Furthermore, compounds 1 and 2 showed weak activity toward brine shrimp (Artemia salina).
14 citations
TL;DR: A series of tirucallane triterpenoids isolated from the stem barks of Aphanamixis grandifolia were assessed for their anti-inflammatory activity, exhibiting from weak to strong anti- inflammatory activity, by testing their inhibitory effects on nitric oxide production and tumor necrosis factor-α level in lipopolysaccharide induced RAW264.7 murine macrophages.
Abstract: A series of tirucallane triterpenoids isolated from the stem barks of Aphanamixis grandifolia were assessed for their anti-inflammatory activity, exhibiting from weak to strong anti-inflammatory activity, by testing their inhibitory effects on nitric oxide (NO) production and tumor necrosis factor-α (TNF-α) level in lipopolysaccharide (LPS) induced RAW2647 murine macrophages To explore the relationship between the structures and anti-inflammatory activity, a vast pool of molecular descriptors for each isolate were calculated Genetic algorithms (GA) or simulated annealing (SA) based partial least squares (GA-PLS and SA-PLS) algorithms identified some important descriptor combinations, which were correlated with both sets of the anti-inflammatory data by partial least squares 2 (PLS2) method S-Plot was used to visualize the descriptor influence in the PLS2 model, disclosed five most important molecular descriptors, nOHt, RDF150m, lip_violation, Mor32m and JhetZ
13 citations
TL;DR: In this article, two new tirucallane triterpenoids, 2 α-ethoxy-2,3-secotirucalla, 2,29-epoxy-7-ene-23-oxo-3-oic acid (1) and (23E)-2 α-hydroxytirucna-7,23,25-triene-3,one (2), along with the known 2,3secotiriucalla-2.
Abstract: Two new tirucallane triterpenoids, 2 α-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid (1) and (23E)-2 α-hydroxytirucalla-7,23,25-triene-3-one (2), along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione (3), were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS data, and compound 3 was further confirmed by X-ray crystal diffraction analysis. Antimicrobial activities and insecticidal activities of these three compounds were also evaluated. Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56 µg/mL, while compounds 1 and 2 showed insecticidal activity at 100 ppm, with the corrected mortality 79.1% and 60.6%, respectively.
8 citations
TL;DR: In this article, two triterpenoids, 3α,24β,25 trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene (1) and 3α-acetoxy-21β-methoxy,24,25,26,27-tetranortirucalli-7 -ene-23(21)-lactone (2), were isolated from the stem barks of Aphanamixis grandifolia, and their structures were elucidated on the basis of spect
Abstract: Two new tirucallane-type triterpenoids, 3α,24β,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene (1) and 3α-acetoxy-21β-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone (2), were isolated from the stem barks of Aphanamixis grandifolia, and their structures were elucidated on the basis of spectroscopic data analysis including 1D, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.
8 citations