Showing papers on "Aphanamixis published in 2014"
TL;DR: Aphadilactones A-D (1-4), four diastereoisomers possessing an unprecedented carbon skeleton, were isolated from the Meliaceae plant Aphanamixis grandifolia and showed significant antimalarial activities and the strongest natural DGAT-1 inhibitor discovered to date.
Abstract: Aphadilactones A-D (1-4), four diastereoisomers possessing an unprecedented carbon skeleton, were isolated from the Meliaceae plant Aphanamixis grandifolia. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chemical degradation, fragment synthesis, experimental CD spectra, and ECD calculations. Aphadilactone C (3) with the 5S,11S,5'S,11'S configuration showed potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 μM, selectivity index > 217) and is the strongest natural DGAT-1 inhibitor discovered to date. In addition, compounds 1-4 showed significant antimalarial activities with IC50 values of 190 ± 60, 1350 ± 150, 170 ± 10, and 120 ± 50 nM, respectively.
37 citations
TL;DR: There were more genetic entities than species described in Aglaia, which shows that the taxonomy of this group is more complex than has sometimes been previously assumed.
21 citations
TL;DR: Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids and are the first example of norsesquiterpenoid with δ-lactone moiety and a class of acyclic diter penoids, which are structurally related nemoralisin C and Nemoralisin.
16 citations
TL;DR: In this article, 25 highly oxygenated prieurianin-type limonoids, zaphaprinins A-Y (1, 25), were isolated from the fruits of Aphanamixis grandifolia.
12 citations
TL;DR: In this article, the exact configuration of 1 was determined by comparison the experimental and calculated electronic circular dichroism (ECD) spectra of Aphanamixis grandifolia.
Abstract: Five new limonoids, aphagranols D–H (1–5, resp.), were isolated from the EtOH extract of the fruits of Aphanamixis grandifolia by chromatographic methods. Their structures were established on the basis of extensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison the experimental and calculated electronic circular dichroism (ECD) spectra. All of the isolates were evaluated for insecticidal activities.
7 citations
TL;DR: Nemoralisin J (4) exhibited moderate inhibitory activity against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC50 value of 9.96 mu as mentioned in this paper.
7 citations
TL;DR: In this article, the title compounds showed significant inhibition on NO production on LPS-activated RAW264.7 cells, which is the state-of-the-art for NO inhibition.
Abstract: The title compounds show significant inhibition on NO production on LPS-activated RAW264.7 cells.
TL;DR: Aphagranols A (I) and B (II) were isolated and their structure was determined using spectroscopic methods and confirmed by comparison to their acetylated derivative as mentioned in this paper.
Abstract: Aphagranols A (I) and B (II) are isolated and their structure is determined using spectroscopic methods and confirmed by comparison to their acetylated derivative.