Aphanamixis

About: Aphanamixis is a research topic. Over the lifetime, 62 publications have been published within this topic receiving 1117 citations.

Antimalarial Diterpenoid Dimers of a New Carbon Skeleton from Aphanamixis grandifolia.

Abstract: Chemical investigation into the minor constituents of Aphanamixis grandifolia yielded three new diterpenoid dimers, aphadilactones E-G (1-3) featuring a new carbon skeleton. Their structures and absolute configurations were fully established by comprehensive spectroscopic data analysis and ECD calculation. Discovery of another two new dimers (4 and 5) suggested the structure of recently reported aphanamene A to be re-investigated. Compounds 1-5 showed moderate antimalarial activities with low micromolar IC50 values.

Aphagranols D—H: Five New Limonoids from the Fruits of Aphanamixis grandifolia

Abstract: Five new limonoids, aphagranols D–H (1–5, resp.), were isolated from the EtOH extract of the fruits of Aphanamixis grandifolia by chromatographic methods. Their structures were established on the basis of extensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison the experimental and calculated electronic circular dichroism (ECD) spectra. All of the isolates were evaluated for insecticidal activities.

Short Communication Analgesic activity of the ethanolic extract of Aphanamixis polystachya bark

Abstract: SUMMARY Ethanolic extract of Aphanamixis polystachya bark was used to investigate its analgesic activity byacetic acid induced writhing in mice. The bark extract exhibited statistically significant and dosedependent analgesic activity in mice. The bark extract at the doses of 250 and 500 mg/kg bodyweight showed 40.69% and 62.07% writhing inhibition respectively in mice whereas diclofenac-Na produced 75.17% writhing inhibition as a positive control. Key words: Aphanamixis polystachya; Acetic acid induced writhing INTRODUCTION Aphanamixis polystachya (Meliaceae), commonlyknown as ‘Roina’, is a large timber tree withbunches of rounded locular fruits and glossy deepbrown seeds and widely distributed in India,China and Bangladesh (Ghani, 2003). Ethanolicextract of the stem possesses anti-cancer propertiesand that bark is an effective immunosuppressive,showed anti-tumours and abdominal complaints.Seed extract possesses antibacterial and antifungalproperties and also used as a liniment of rheumatism(Ghaini, 2003; Rabi and Gupta, 1995). A number ofchemical constituents have been reported in thisplant such as rohitukin, limonoids, amooranin,tetranotriterpene and aphanamixinin (Chatterjee etal., 1970; Mulholand and Naidoo, 1999; Ghani,2003; Rabi et al., 2003).As part of our on-going pharmacological screeningof randomly selected Bangladeshi medicinal plants(Uddin et al., 2004, 2005; Shilpi et al., 2005; Rouf etal., 2006, 2007 ), we now report on the investigationof analgesic activity of Aphanamixis polystachyabark extract.

Novel Nortriterpenoids form Aphanamixis grandifolia.

Abstract: Four novel tircullane-type nortriterpenoids (I)—(IV) are isolated together with previously known mombasol.