Topic
Aphanamixis
About: Aphanamixis is a research topic. Over the lifetime, 62 publications have been published within this topic receiving 1117 citations.
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TL;DR: From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I-M, one new apo-tirucallane-type triterpenoid, polystanin E, and three new chain-like diterpenoids, nemoralisins A-C, along with 12 known compounds were identified.
Abstract: From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I–M (1–5), one new apo-tirucallane-type triterpenoid, polystanin E (6), and three new chain-like diterpenoids, nemoralisins A–C (7–9), along with 12 known compounds were identified. The absolute configurations were determined by a combination of single-crystal X-ray diffraction studies, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, the Mosher ester method, and calculated ECD data. The cytotoxicities of all the isolates and the insecticidal activities of the limonoids were evaluated.
44 citations
TL;DR: Five tirucallane type C(26) triterpenoids, accompanied by two known compounds, were isolated from the stem barks of Aphanamixis grandifolia and in vitro evaluated for their cytotoxic activities against five tumor cell lines.
39 citations
TL;DR: Aphadilactones A-D (1-4), four diastereoisomers possessing an unprecedented carbon skeleton, were isolated from the Meliaceae plant Aphanamixis grandifolia and showed significant antimalarial activities and the strongest natural DGAT-1 inhibitor discovered to date.
Abstract: Aphadilactones A-D (1-4), four diastereoisomers possessing an unprecedented carbon skeleton, were isolated from the Meliaceae plant Aphanamixis grandifolia. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chemical degradation, fragment synthesis, experimental CD spectra, and ECD calculations. Aphadilactone C (3) with the 5S,11S,5'S,11'S configuration showed potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 μM, selectivity index > 217) and is the strongest natural DGAT-1 inhibitor discovered to date. In addition, compounds 1-4 showed significant antimalarial activities with IC50 values of 190 ± 60, 1350 ± 150, 170 ± 10, and 120 ± 50 nM, respectively.
37 citations
TL;DR: Within the series of phytosterol derivatives tested, compound 15 was the most active, displaying potent cytotoxicity against HL-60 with IC(50) of 5.10μmol/L, and most of the active compounds showed selective cytot toxicity against tumor and non-tumor cell lines, especially compound 10 with a safety index of 4.42.
37 citations
TL;DR: Two new limonoids, namely aphanamolides A and B, were isolated from the seeds of Aphanamixis polystachya and featured an unprecedented carbon skeleton via the formation of a C-3-C-6 bond.
35 citations