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Aphanamixis polystachya
About: Aphanamixis polystachya is a research topic. Over the lifetime, 86 publications have been published within this topic receiving 1510 citations.
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TL;DR: Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive tochloroquine (W2) and one chloroquine-resistant (D6), suggesting there is no cross-resistance to chloroquines.
Abstract: Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive to chloroquine (W2) and one chloroquine-resistant (D6). Twelve extracts were found to have activity, including extracts of Cedrela odorata wood and Azadirachta indica leaves, which contained the limonoid gedunin. These extracts were more effective against the W2 clone than the D6 clone, suggesting there is no cross-resistance to chloroquine. Gedunin was extracted in quantity, and nine derivatives prepared for a structure-activity study, which revealed essential functionalities for activity. The study also included four other limonoids derived from related Meliaceae. Only gedunin had better activity than chloroquine against the W2 clone. This active principle could be used to standardize a popular crude drug based on traditional use of A. indica in West Africa.
196 citations
TL;DR: The ethanol extract was the most toxic of four extracts tested and showed the lowest LD 50 value, and the ground leaves, bark and seeds in a 2.5% mixture provided some protection for wheat flour by reducing F1 progeny.
141 citations
TL;DR: Results of three different bioassays showed that crude extracts of pithraj seeds have strong repellent effects and moderate feeding deterrent and insecticidal effects on adult Tribolium castaneum.
Abstract: Laboratory experiments were carried out to investigate the efficacy of seed extracts of pithraj,Aphanamixis polystachya (Wall & Parker), a locally grown plant in Bangladesh, against the red flour beetle,Tribolium castaneum (Herbst.). Results of three different bioassays showed that crude extracts of pithraj seeds have strong repellent effects and moderate feeding deterrent and insecticidal (direct-contact) effects on adultTribolium castaneum.
129 citations
TL;DR: In this paper, the authors compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-plymphoid Jurkat, and HEL cell lines.
Abstract: In this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, erythroleukemic HEL cell lines. Extracts from Emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from Terminalia arjuna, Aphanamixis polystachya, Oroxylum indicum, Cuscuta reflexa, Aegle marmelos, Saraca asoka, Rumex maritimus, Lagerstroemia speciosa, Red Sandalwood. Emblica officinalis extracts have been studied previously, due to their hepatoprotective, antioxidant, antifungal, antimicrobial and anti-inflammatory medicinal activities. Gas chromatography/mass spectrometry analyses allowed to identify pyrogallol as the common compound present both in unfractionated and n-butanol fraction of Emblica officinalis extracts. Antiproliferative effects of pyrogallol were therefore determined on human tumor cell lines thus identifying pyrogallol as an active component of Emblica officinalis extracts.
123 citations
TL;DR: The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera suggested it may be a potent defensive component of A. polystachya.
89 citations