Topic
Aphasia
About: Aphasia is a research topic. Over the lifetime, 13727 publications have been published within this topic receiving 388249 citations.
Papers published on a yearly basis
Papers
More filters
•
[...]
01 Jan 2001
TL;DR: A process for isolating a thromboplastic material from human placentae by solvent extraction techniques and it is obtained that is useful as a blood coagulant is obtained.
4,586 citations
••
University of Trento1, University of California, San Francisco2, Johns Hopkins University3, Northwestern University4, University of Western Ontario5, University of California, Los Angeles6, Vita-Salute San Raffaele University7, University College London8, University of Toronto9, Mayo Clinic10, University of California, Davis11, Katholieke Universiteit Leuven12, University of Cambridge13, University of New South Wales14, University of Pennsylvania15
TL;DR: This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results.
Abstract: This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for the 3 variants of PPA—nonfluent/agrammatic, semantic, and logopenic—were developed by an international group of PPA investigators who convened on 3 occasions to operationalize earlier published clinical descriptions for PPA subtypes. Patients are first diagnosed with PPA and are then divided into clinical variants based on specific speech and language features characteristic of each subtype. Classification can then be further specified as “imaging-supported” if the expected pattern of atrophy is found and “with definite pathology” if pathologic or genetic data are available. The working recommendations are presented in lists of features, and suggested assessment tasks are also provided. These recommendations have been widely agreed upon by a large group of experts and should be used to ensure consistency of PPA classification in future studies. Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations.
3,635 citations
•
01 Jan 1972
TL;DR: This small volume is designed as an introduction to the Boston Diagnostic Aphasia Test and deals briefly with the authors' concept of aphasia as a neuropsychological, psycholinguistic phenomena.
Abstract: Originally published in Contemporary Psychology: APA Review of Books, 1972, Vol 17(11), 614. Reviews the book, The Assessment of Aphasia and Related Disorders by Harold Goodglass (1972). This small volume is designed as an introduction to the Boston Diagnostic Aphasia Test. It deals briefly with the authors' concept of aphasia as a neuropsychological, psycholinguistic phenomena. (PsycINFO Database Record (c) 2006 APA, all rights reserved)
3,386 citations
••
1,760 citations
••
TL;DR: The anatomical findings are relevant to the evolution of language, provide a framework for Lichtheim's symptom‐based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language.
Abstract: Early anatomically based models of language consisted of an arcuate tract connecting Broca's speech and Wernicke's comprehension centers; a lesion of the tract resulted in conduction aphasia. However, the heterogeneous clinical presentations of conduction aphasia suggest a greater complexity of perisylvian anatomical connections than allowed for in the classical anatomical model. This article re-explores perisylvian language connectivity using in vivo diffusion tensor magnetic resonance imaging tractography. Diffusion tensor magnetic resonance imaging data from 11 right-handed healthy male subjects were averaged, and the arcuate fasciculus of the left hemisphere reconstructed from this data using an interactive dissection technique. Beyond the classical arcuate pathway connecting Broca's and Wernicke's areas directly, we show a previously undescribed, indirect pathway passing through inferior parietal cortex. The indirect pathway runs parallel and lateral to the classical arcuate fasciculus and is composed of an anterior segment connecting Broca's territory with the inferior parietal lobe and a posterior segment connecting the inferior parietal lobe to Wernicke's territory. This model of two parallel pathways helps explain the diverse clinical presentations of conduction aphasia. The anatomical findings are also relevant to the evolution of language, provide a framework for Lichtheim's symptom-based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language. Ann Neurol 2005
1,653 citations