Topic
Apical cytoplasm
About: Apical cytoplasm is a research topic. Over the lifetime, 1080 publications have been published within this topic receiving 36131 citations.
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TL;DR: It is suggested that regional differentiation of the organization of F-actin network is related to the differing kinematics of the spine at different levels.
3 citations
TL;DR: The cytoskeletal structures in the apical region of mouse taste bud cells were examined by immunocytochemistry and electron microscopy and showed positive reactions for actin, indicating these filaments to be composed of actin.
Abstract: The cytoskeletal structures in the apical region of mouse taste bud cells were examined by immunocytochemistry and electron microscopy. Immunostaining for actin showed positive reactions in the apical portions of the taste buds. These regions contained bundles of longitudinally oriented filaments (5-7 nm in diameter) extending from the tip of microvilli to the apical cytoplasm of type-I, -II, and-III cells. After incubation with heavy meromyosin, arrowhead formation was observed along these filaments, thus indicating these filaments to be composed of actin. The plasmalemmal undercoat, which was composed of vertical and horizontal layers, was observed on the zonula occludens. It is supposed that this undercoat gives the structural support for the lateral membrane of the apical region in the taste bud cells.
3 citations
TL;DR: Although 5 α-dihydrotestosterone and 5α-androstane-3α, 17β-diol maintained the presence of secretory granules in the apical cytoplasm of cells in the posterior prostate, they did not preserve the highly infolded nature of the nuclear envelope characteristic of the nucleus of intact controls.
3 citations
01 Jan 1983
TL;DR: The ultrastructural localization of adenylate cyclase and cAMP phosphodiesterase in the ectoderm of the developmental stage 4 chick embryo was studied and the enzymatic activity was observed on all the lateral surfaces.
Abstract: The ultrastructural localization of adenylate cyclase (E.C. 4.6.1.1.) and cAMP phosphodiesterase (PDE) (E.C. 3.1.4.17.) in the ectoderm of the developmental stage 4 chick embryo was studied. Adenylate cyclase was localized in the lateral surfaces of the ectodermal cells. In the primitive streak cells the enzymatic activity was observed on all the lateral surfaces, whereas in the periphery of the blastoderm the reaction product was localized in the apical parts of the lateral plasma membranes only.cAMP PDE localized in the apical cytoplasm of the ectodermal cells, with highest activity in the globular projections.
3 citations
TL;DR: Cloning the mouse and human BM180 gene will aid molecular investigation of lacrimal acinar cell-BM180 interactions and may lead to a new molecular understanding of mechanisms contributing to dry eye.
Abstract: Dry eye is the ocular manifestation of a collective secretory deficiency by lacrimal acinar cells.1 Lacrimal acinar cells are polarized tear protein factories, with tear protein-filled secretory granules packed in the apical cytoplasm adjacent to the acinar lumen into which tear proteins are released. These cells are wrapped into acini by a poorly characterized basement membrane2 sheet, the complex cellular adhesiveness of which is the molecular basis for exocrine cell polarity.3 Abnormality of the basement membrane-cell interface is the primary lesion in several autoimmune and genetic diseases.4 In Goodpasture’s syndrome, for example, nephrotoxic autoantibodies appear as a consequence of infection-associated exposure of a sequestered epitope in the α3 chain of collagen IV. In Alport’s syndrome, function-altering point mutations in the collagen IV α3 chain have been detected.
3 citations