Topic
Apiin
About: Apiin is a research topic. Over the lifetime, 61 publications have been published within this topic receiving 2219 citations. The topic is also known as: 7-((2-O-beta-D-Apiofuranosyl-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyranone & apigenin 7-O-[beta-D-apiosyl-(1->2)-beta-D-glucoside].
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TL;DR: A novel strategy for the biological synthesis of anisotropic gold and quasi-spherical silver nanoparticles by using apiin as the reducing and stabilizing agent is reported, expected to be of application in hyperthermia of cancer cells and in IR-absorbing optical coatings.
494 citations
TL;DR: In this article, the influence of six pressurized liquid extraction parameters (temperature, pressure, particle size, flush volume, static time, and solid-to-solvent ratio) on the extraction of phenolic compounds from parsley flakes was examined.
176 citations
TL;DR: In cell suspension cultures of parsley the degree of increase of activity of phenylalanine ammonia-lyase caused by white light depends on the growth stage of the cultures, and two groups of enzymes could be distinguished on the basis of their responses to light.
167 citations
TL;DR: A small portion of apigenin provided by food reaches the human circulation and, therefore, may reveal biological effects, and was detected in red blood cells without showing dose-response characteristics.
Abstract: Aim: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. Methods: Eleven healthy subjects (5 women, 6 men) in the age range of 23–41 years and with an average body mass index of 23.9 ± 4.1 kg/m2 took part in this study. After an apigenin- and luteolin-free diet, a single oral bolus of 2 g blanched parsley (corresponding to 65.8 ± 15.5 µmol apigenin) per kilogram body weight was consumed. Blood samples were taken at 0, 4, 6, 7, 8, 9, 10, 11 and 28 h after parsley consumption and 24-hour urine samples were collected. Apigenin was analyzed in plasma, urine and red blood cells by means of HPLC-ECD. Results: On average, a maximum apigenin plasma concentration of 127 ± 81 nmol/l was reached after 7.2 ± 1.3 h with a high range of variation between subjects. For all participants, plasma apigenin concentration rose after bolus ingestion and fell within 28 h under the detection limit (2.3 nmol/l). The average apigenin content in 24-hour urine was 144 ± 110 nmol/24 h corresponding to 0.22 ± 0.16% of the ingested dose. The flavone could be detected in red blood cells without showing dose-response characteristics. Conclusions: A small portion of apigenin provided by food reaches the human circulation and, therefore, may reveal biological effects.
162 citations
TL;DR: The immunomodulatory bioassay-guided fractionation of the methanolic extract of henna resulted in the isolation of seven compounds, three of which have been isolated for the first time from the genus, namely p-coumaric acid, 2-methoxy-3-methyl-1,4-naphthoquinone and apiin.
Abstract: The immunomodulatory bioassay-guided fractionation of the methanolic extract of henna (Lawsonia inermis L.; syn. Lawsonia alba L.) leaves resulted in the isolation of seven compounds; three have been isolated for the first time from the genus, namely p-coumaric acid, 2-methoxy-3-methyl-1,4-naphthoquinone and apiin, along with the previously isolated compounds: lawsone, apigenin, luteolin, and cosmosiin. Structural elucidation of the isolated compounds was based upon their physical, chemical as well as spectroscopic characters. Their immuomodulatory profile was studied using an in vitro immunoassay, the lymphocyte transformation assay. The ABTS [2,2'-azino-bis (3-ethyl benzthiazoline-6-sulfonic acid)], free radical scavenging assay depicted that all isolated compounds exhibited antioxidant activity comparable to that of ascorbic acid.
143 citations