Aquation

About: Aquation is a research topic. Over the lifetime, 1443 publications have been published within this topic receiving 17507 citations.

Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers.

Abstract: The first observation of a polyamine–DNA interaction using 2D [1H, 15N] HSQC NMR spectroscopy allows study of the role of the linker in polynuclear platinum-DNA interactions and a novel “anchoring” of the polyamine by Pt–DNA bond formation allows examination of the details of conformational B → Z transitions induced by the polyamine. The kinetics and mechanism of the stepwise formation of 5′-5′ 1,4-GG interstrand cross-links (IXLs) by fully 15N-labeled [{trans-PtCl(15NH3)2}2{μ-(15NH2(CH2)615NH2(CH2)615NH2)}]3+ (1,1/t,t-6,6, 1) and [{trans-PtCl(15NH3)2}2{μ-(15NH2(CH2)615NH2(CH2)215NH2(CH2)615NH2)}]4+ (1,1/t,t–6,2,6, 1′) with the self-complementary oligonucleotide 5′-{d(ATATGTACATAT)2} (duplex I) are compared to the analogous reaction with 1,0,1/t,t,t (BBR3464) under identical conditions (pH 5.4, 298 K). Initial electrostatic interactions with the DNA are delocalized and followed by aquation to form the monoaqua monochloro species. The rate constant for monofunctional adduct formation, kMF, for 1 (0.87 M–1 ...

The preparation of hydridopentammine- and hydridoaquotetramminerhodium(III) sulphates and other salts; the formation of alkyl and fluoroalkyl derivatives

Abstract: The action of metallic zinc on ammoniacal solutions of chloropentamminerhodium chloride in presence of sulphate ion leads to the formation of hydridopentamminerhodium(III) sulphate Several other salts of the cation have been preparedThe pentammine undergoes an aquation reaction to form the aquo-ion [Rh(NH3)4(H2O)H]2+ in which the water is trans to the hydrido-groupThe interaction of the hydrido-species with ethylene, propene, and but-I-ene and with tetrafluoroethylene and other fluoro-olefins has been studied and crystalline salts have been isolated The ir and nmr spectra of certain of these species are given, and the electronic spectra discussed