Showing papers on "Arecoline published in 1971"
TL;DR: Both haloperidol and arecoline induced a cataleptic state in rats and a marked synergistic effect was observed upon combination of threshold doses of these two drugs, with possible role of the extrapyramidal system.
158 citations
TL;DR: Results from these and previous experiments indicate that the caudate-putamen and substantia nigra are involved in the mechanism by which cholinergic drugs can mimic and synergize with neuroleptic drugs.
57 citations
TL;DR: Tritiation of arecoline hydrochloride by catalytic exchange in aqueous media gave arecaidine hydro chloride of high specific radioactivity and the (3)H]Arecoline 1-oxide gave the same metabolities, but in different amounts.
Abstract: 1. Tritiation of arecoline hydrochloride by catalytic exchange in aqueous media (done by The Radiochemical Centre) gave arecaidine hydrochloride of high specific radioactivity; this on treatment with diazomethane gave [3H]arecoline, which was oxidized with peroxyacetic acid to [3H]arecoline 1-oxide. 2. Arecoline 1-oxide gave arecaidine 1-oxide on acid hydrolysis and 1,2-dihydro-1-methylnicotinic acid methyl ester on thermal decomposition. 3. [3H]Arecoline hydrochloride was metabolized in the rat into the 3H-labelled derivatives of arecoline 1-oxide, arecaidine 1-oxide, arecaidine, N-acetyl-S-(3-carboxy-1-methylpiperid-4-yl)-l-cysteine and an unidentified metabolite; some unchanged arecoline was also excreted. [3H]Arecoline 1-oxide gave the same metabolities, but in different amounts. 4. The possible relevance of these findings to betel-nut carcinogenesis is discussed.
50 citations
TL;DR: It is concluded that nicotinic and muscarinic steps are involved in cholinergic neurological processes promoting catalepsy.
44 citations
TL;DR: The results provide behavioral evidence for the possible existence of specific m -and n -cholinergic receptors in the central nervous system.
29 citations
TL;DR: Recordings were made of the heart-beat of Patella vulgata under the influence of a range of cholinergic agonists and antagonists, mainly muscarinic, although a nicotinic agonist, lobeline, also inhibited the beat.
14 citations
Journal Article•
1 citations