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Showing papers on "Arecoline published in 1980"


Journal ArticleDOI
TL;DR: The results strongly suggest that there exist nicotinic cholinergic receptors in brain synaptic regions which play an important role in the function of hypothalamus by releasing noradrenaline and that the release mechanism of nor adrenaline induced by nicotine is different from that induced by reserpine and tyramine.

90 citations


Journal ArticleDOI
TL;DR: Offspring of pregnant rats injected with haloperidol or saline throughout gestation and until weaning were psychopharmacologically tested for their responsiveness to arecoline and apomorphine, suggesting that chronic dopamine receptor blockade during development may have long-term indirect effects on the sensitivity of the cholinergic system.
Abstract: Offspring of pregnant rats injected with 0.25 mg/kg of haloperidol or saline throughout gestation and until weaning were psychopharmacologically tested for their responsiveness to arecoline and apomorphine. On postnatal day 50, offspring of such chronic treatments were tested in the open field after administration of 0, 0.05, 0.1, 1.0 or 3.0 mg/kg apomorphine, a dopamine agonist. The two chronic treatment groups did not differ in response to high doses of apomorphine which induced stereotyped sniffing and a depression of matrix crossing behavior. However, while control offspring exhibited a low dose (0.05 mg/kg apomorphine) suppression of matrix crossings and rearing behavior, haloperidol treated offspring did not, which may indicate a functional hyposensitivity of dopaminergic autoreceptors in these treated animals. When tested at postnatal day 65 for their cataleptic responses to the cholinergic agonist arecoline, haloperidol treated offspring were more cataleptic to 2 and 5 mg/kg arecoline than control offspring. This suggests that chronic dopamine receptor blockade during development may have long-term indirect effects on the sensitivity of the cholinergic system.

25 citations



Journal Article
TL;DR: It is concluded that the evoked field potentials in the dentate gyrus of immobilized rats are elicited by cholinergic muscarinic activation.
Abstract: We reported previously the elicitation of presumably monosynaptic evoked field potentials in the dentate gyrus of immobilized rats by stimulation of the medial septal nuclei. The septo-hippocampal pathway mediating this evoked potential (SHEP) is widely assumed to be cholinergic in nature. In order to further verify this assumption we studied the effects of muscarinic drugs on the SHEPs. Scopolamine as muscarinic cholinolytic and arecoline as muscarinic cholinergic agent influenced the SHEP in the expected manner. We conclude that the SHEP is elicited by cholinergic muscarinic activation.

3 citations


Journal ArticleDOI
TL;DR: In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be causually related to its anti‐tremor action, revealing a possibility for the development of peripherally acting anti‐Parkinson drugs.
Abstract: 1 Anti-tremor action of decamethylene bis-(hydroxyethyl)-dimethylammonium bromide (C10Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C10Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine-induced mortality in mice. 3 In non-paralysing doses, C10Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C10Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be casually related to its anti-tremor action. 6 This study reveals a possibility for the development of peripherally acting anti-Parkinson drugs.

1 citations