Showing papers on "Arecoline published in 1999"
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TL;DR: The results of this study are compatible with models that propose that serotonin innervation from the median raphe drives GABA interneurons in the medial septum that synapse on cholinergic neurons projecting to the hippocampus.
52 citations
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TL;DR: Results indicate that cytotoxicity of arecoline on OMF is associated with cellular GSH levels and esterase activities and factors that induce the GSH synthesis or ester enzyme activity of oral mucosal cells can be used for future chemoprevention of BQ chewing-related lesions.
47 citations
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TL;DR: Results indicate that arecoline is a cytotoxic agent to human gingival fibroblasts, and Repeated and long-term exposure to are coline could impair gingivals fibroblast function.
Abstract: Arecoline, a major betel nut alkaloid, has been detected in saliva obtained during betel nut chewing in concentrations up to 140 μg/ml, corresponding to 0.9 mM. Arecoline in the millimolar concentration range might participate in the initiation and/or progression of periodontal disease during the long-term effects of betel nut chewing. In this study, cell growth, cell proliferation, assessment of cytoplasmic enzyme lactate dehydrogenase (LDH) and collagen synthesis were used to investigate the effects of human gingival fibroblasts exposed to arecoline levels of 0–200 μg/ml. Control culture exhibited a normal monolayer of long spindle-shaped fibroblast morphology. Arecoline-treated human gingival fibroblasts showed a more rounded appearance and detached at the higher concentrations. At concentrations higher than 75 μg/ml, many cells had detached from the surface of the petri dish and numerous floating cells could be seen under the inverted microscope. At a concentrations higher than 25 μg/ml, arecoline inhibited cell growth, proliferation and collagen synthesis and increased LDH leakage in a dose-dependent manner (P<0.05). These results indicate that arecoline is a cytotoxic agent to human gingival fibroblasts. Repeated and long-term exposure to arecoline could impair gingival fibroblast function. Betel quid chewers might be more susceptible to destruction of the periodontium and less responsive to a regeneration procedures during periodontal therapy.
37 citations
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TL;DR: The data indicate that ARC-OA induced a higher frequency of cancers, a greater delay in the cell cycle and greater sister chromatid exchanges than ARC-IP.
33 citations
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TL;DR: While most proteins showed lowering of their poly-ADP-ribosylation following arecoline treatment, only histone protein H1 in spleen cells and H2B in bone marrow cells exhibited an increase, and the chromatin of both the tissues was progressively relaxed upon areColine exposure.
29 citations
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13 citations
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TL;DR: Nicotine and arecoline significantly increased IL-1 alpha and -1 beta secretions and the surface expression of ICAM-1 in KB CCL17 cells.
9 citations
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TL;DR: The increasing-effect components for molluscicides isolated from the dry nut of Areca catech L. were studied and arecoline was the most effective and it could decrease remarkably the amount of drugs i.e. saponium of Phytolacca acinosa, SPA, and sodium pentachloro phenate, NaPCP, when used together.
Abstract: The increasing-effect components for molluscicides isolated from the dry nut of Areca catech L. were studied. The results showed that arecoline was the most effective and it could decrease remarkably the amount of drugs i.e. saponium of Phytolacca acinosa, SPA, and sodium pentachloro phenate, NaPCP, when used together.
7 citations
01 Jan 1999
TL;DR: It has been proved that Arecoline significantly enhances spontaneous contraction of isolated ileum in guinea pigs, and has doseeffect dependence relationship.
Abstract: Arecoline is a muscarineCholinergic receptorstimulantIt has been proved that Arecoline significantly enhances spontaneous contraction of isolated ileum in guinea pigs, and has doseeffect dependence relationshipThe effect of Arecoline on enchancing the contraction amplitude of isolated ileum is significant, but the effect of enchancing the contraction frequency is little95.2 mg/kg PO of Arecoline continuously for 7 days had no adverse effect in miceThis dosage is 13.8 times as much as the clinical dosage in human beings
4 citations
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TL;DR: The potency, relative efficacy, and receptor subtype selectivity of these compounds were related to the structure of the O-substituents and the position and stereochemical orientation of the piperidine ring methyl substituents.
3 citations
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TL;DR: There might be a special, possibly mixed muscarinic/nicotinic ACh-receptor system in the myocytes of the bulbus cordis branchialis, which is different from the cholinergic receptor in the central part of the branchial heart.
Abstract: In vitro experiments were performed on a standardized preparation of the autonomously contractile bulbus cordis branchialis of the branchial heart of Sepia officinalis to investigate its cholinergic neuroregulation. Apart from acetylcholine, nicotine and carbachol (nicotinic agonists), the muscarinic agonists muscarine, arecoline, pilocarpine, and oxotremorine also exerted concentration-dependent negative inotropic effects on the preparations. As both the muscarinic antagonist quinuclidinylbenzilate and the nicotinic antagonist alpha-bungarotoxin blocked the ACh action there might be a special, possibly mixed muscarinic/nicotinic ACh-receptor system in the myocytes of the bulbus cordis branchialis, which is different from the cholinergic receptor in the central part of the branchial heart.