Topic
Arecoline
About: Arecoline is a research topic. Over the lifetime, 744 publications have been published within this topic receiving 16015 citations. The topic is also known as: methylarecaiden & methylarecaidin.
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TL;DR: Wang et al. as discussed by the authors studied the molluscicidal activity and mechanisms of arecoline against P. canaliculata, and the LC50 value (72 h) was 1.05 mg/L (15 ± 2 mm shell diameter).
2 citations
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21 Nov 2020
TL;DR: Findings showed that the downregulation of CYP26A1 mRNA and protein expression are more frequently observed in cancerous tissues than adjacent normal tissues in patients with oral and pharynx cancers, and arecoline appears to modulate CYP 26A1 expression through specific pathways.
Abstract: Betel quid (BQ) has been classified as a Group I human carcinogen in light of evidence demonstrating an association with an elevated risk of oral and pharyngeal cancers. To date, the incidence rate of oral and pharynx cancers among Taiwanese men ranks the highest worldwide. However, no study has yet confirmed variants of CYP26A1 was associated with the risks of oral and pharyngeal cancers. A case-control study was conducted (n = 339). CYP26A1 polymorphism was performed using SNP assay. Real-time qRT-PCR and Western blotting were used to determine the levels of CYP26A1 expression. The cancer cell model involved treatment with arecoline. Our findings showed that the downregulation of CYP26A1 mRNA and protein expression are more frequently observed in cancerous tissues than adjacent normal tissues in patients with oral and pharynx cancers (p < 0.01). We found that CYP26A1 was downregulated as the arecoline dose increased. We hypothesized that lower levels of CYP26A1 mRNA expression can be utilized a clinically biomarker causes oral and pharynx cancers. Arecoline appears to modulate CYP26A1 expression through specific pathways. Carriers of CYP26A1 SNP, rs2068888 (G/G)/rs4418728 (G/G) and who have lower levels of CYP26A1 expression are associated with an increased risk of oral and pharyngeal cancers.
2 citations
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TL;DR: In this paper , the authors conducted a comprehensive assessment of the combined hazardous effects of areca nut (AN) alkaloids and aflatoxins towards human digestive system, by methods of HPLC analysis, cell study and in vitro digestive system study.
2 citations
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TL;DR: In this article , a high-throughput method based on microwave assisted extraction (MAE) and isotope dilution liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed to measure the four biomarkers of betel nuts and cigarettes, including areca alkaloids (arecoline), tobacco alkaloid (nicotine), and their metabolites (arecaidine and cotinine).
2 citations
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01 Jul 2020TL;DR: The muscarinic receptors gar-2 and gar-3 are not required for suppression of acr-2(gf) by arecoline, and loss of function in genes involved in GABAergic synaptic transmission eliminates suppression.
Abstract: Figure 1: (A) The muscarinic receptors gar-2 and gar-3 are not required for suppression of acr-2(gf) by arecoline. (B) Pre-treatment with the specific muscarinic antagonist atropine does not affect suppression of acr-2(gf) by arecoline. (C) Loss of function in genes involved in GABAergic synaptic transmission eliminates suppression of acr-2(gf) by arecoline. (D) A new unc-49(ju1617) mutation was isolated in a genetic screen for mutants preventing suppression of acr-2(gf) by arecoline. Two-way ANOVA, ***P<0.001, **P<0.01, *P<0.05, n.s.=not significant.
2 citations