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Arecoline

About: Arecoline is a research topic. Over the lifetime, 744 publications have been published within this topic receiving 16015 citations. The topic is also known as: methylarecaiden & methylarecaidin.


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Patent
16 May 2003
TL;DR: A skin whitening composition containing arecoline capable of being obtained from Areca catechu L. is provided in this article, which prevents pigmentation by inhibiting the formation of melamine without adverse effect.
Abstract: PURPOSE: A skin whitening composition containing, as an active ingredient, arecoline capable of being obtained from Areca catechu L. is provided. The composition prevents pigmentation by inhibiting the formation of melamine without adverse effect and is thus effective for skin whitening or improvement of chloasma or freckles. CONSTITUTION: The skin whitening composition contains 0.000001 to 10% by weight of arecoline(1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid methyl ester) of the formula(1) commonly known as an agent for treating disorders caused by cerebral ischemia including stroke, alcohol craving, decreased memory function etc., based on the total weight of the composition. The arecoline is obtained by extracting Areca catechu L. in a solvent selected from the group consisting of C1-4 lower alcohol, ethyl acetate, acetone, ether, benzene, chloroform, hexane, cyclohexane and petroleum ether.

1 citations

DOI
26 Jun 2020
TL;DR: Convulsion rate for acr-2(gf) animals cultured on nematode growth media (NGM) supplemented with 1mM, 5MM, or 15mM arecoline, compared to no drug control and varied effects of cholinergic agonists on convulsions.
Abstract: Figure 1: (A) Shown is the convulsion rate for acr-2(gf) animals cultured on nematode growth media (NGM) supplemented with 1mM, 5mM, or 15mM arecoline, compared to no drug control. (B) Shown is the convulsion rate of acr-2(gf) animals treated with 15mM arecoline on NGM plates for 3hrs, then transferred to drug-free plates, and scored after the indicated time post-arecoline treatment. (C) Varied effects of cholinergic agonists on convulsions of acr-2(gf) animals. Convulsions were scored after 3hr of indicated drug treatment. N≥18 * P≤0.05, **P≤0.01, **P≤0.001 Two-way ANOVA followed by Dunnett’s Test. All treatments are compared to those on drug-free NGM plates.

1 citations

Journal Article
TL;DR: Arecoline proved to cause changes in the electrolyte distribution by the depolarization type, whereas amizyl--by the type of hyperpolarization of the nerve cell membrane.
Abstract: A study was made of the activity of Na, K-ATP-ase and the Na+ and K+ content in the brain of rats with the action of arecoline and amizyl. Both arecoline and amizyl increased the Na, K-ATP-ase activity. This could be associated with the changes in the redistribution of the Na+ and K+ ions in the nerve cell. Arecoline proved to cause changes in the electrolyte distribution by the depolarization type, whereas amizyl--by the type of hyperpolarization of the nerve cell membrane.

1 citations

Journal Article
TL;DR: In the acute experiments, the inositol levels of rat submandibular glands were increased by repeating five doses of nicotine at 5 min intervals, which was prevented by nicotinic antagonist mecamylanine, and was inverted by lithium chloride (69.4 mg·kg 1 ip), an inositl phosphatase inhibitor.
Abstract: In the acute experiments, the inositol levels of rat submandibular glands were increased by repeating five doses of nicotine 0.5, 1.0, 1.0, 2.0 and 2.0 mg·kg 1 ip at 5 min intervals, which was prevented by nicotinic antagonist mecamylanine (1.0 mg·kg 1 ip), and was inverted by lithium chloride (69.4 mg·kg 1 ip), an inositol phosphatase inhibitor. Muscarinic agonist arecoline 200 mg·kg 1 ip also increased the inositol levels, which was prevented by muscarinic antagonist atropine (2.0 mg·kg 1 ip). The synergism on the increases in inositol levels of rat submandibular glands was observed between the five doses of nicotine and arecoline 50 mg·kg 1 ip. But in the chronic experiments, the inositol levels were decreased by nicotine 2.0-5.0 mg·kg 1 or arecoline 2.0-10.0 mg·kg 1 sc twice a day for 14 d.

1 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202335
202243
202126
202038
201921
201818