Arecoline

About: Arecoline is a research topic. Over the lifetime, 744 publications have been published within this topic receiving 16015 citations. The topic is also known as: methylarecaiden & methylarecaidin.

Efectos bucales de la nuez de betel oral effects of the betel nut

Abstract: The betel nut or areca nut Is the seed of the palm tree of betele (areca catechu), one of the most popular plants of the world. Asians, by cultural influence, have the custom of chew the seed of this sort of vegetable. Between its active principies: arecaine and arecoline, they are alkaloids comparable to the nicotine in the neural stimulation effects. The active substance causes a pleasant relaxion sensation in the mouth, sensation that is extended to the central nervous system. However, chewing regularly betel nut dryes 01 red the saliva and blackens the teeth being extremely harmful to the mouth health causing early the loss of the teeth. Despite of the harmful effects, the difficulty to eliminate this habit is due to its deep cultural character. Chewing betel nuts and have the teeth stained it 's a motive of proud. The International Agency 01 Research 01 the Cancer {lARC) classifies the betel nut as carcinogenic acquaintance, and the literature have many studies that relate this custom with the oral cancer. The study has as goal to do a critical analysis 01 the utilization of this substance, searching to inlorm to the community their bad effects (Kiru 2012;9(2):167-170).

[Mechanism of the inhibitory effect of acetylcholine and its analogs on sarcolemma Na, K-ATPase].

Abstract: Effect of acetylcholine on Na, K-ATPase from cardiac and skeletal rabbit muscles is studied. The inhibition of the enzyme by acetylcholine was shown to depend on the Na+/K+ ratio and Mg2+ concentration in the incubation medium. The sensitivity of Na, K-ATPase to acetylcholine and its analogues decreased as follows: acetylcholine, propionylcholine butyrylcholine, arecoline, carbacholine, choline. Muscle denervation resulted in 20-fold increase of the enzyme sensitivity to acetylcholine. Preparations of Na, K-ATPase from different muscles have the increasing sensitivity to acetylcholine in the following order: white, mixed, cardiac, denervated muscles.

Study of the impact of pretreatment on arecoline extraction rate

Abstract: An investigation was made on Hainan areca nut. Studied the impact of the degree of maturity, drying methods and milling granularity on the arecoline's extraction rate. Mensurated arecoline's content in areca nut's peel and seed separately. The results showed that: areca nut with six degree of maturity, dried by vacuum freeze and milled to 50 mesh granularity, got the highest arecoline's extraction rate. The content of arecoline in peel was more than that in seed, and the red color of areca nut was from the seed.

Supari Consumption is a Common Oral Habit Among Women in Chabahar City

Abstract: Chewing of areca nuts (Figure 1) in various forms is a common practice in India where areca nut products such as guthka, supari, and betel quid, with or without tobacco (pan) (Figure 2), are easily available. In India, there are regional differences in the consumption of these areca nut products. The nut contains arecoline and other alkaloids that very strongly stimulate the synthesis of collagen by fibroblasts (1, 2). People begin consuming areca nut products (pan, guthka, and supari) at an early age, thereby increasing the risk of oral mucosal fibrosis (OSF). OSF is a precancerous lesion characterized by submucosal fibrosis, reduced levels of vasculature, and mucosal atrophy. The clinical features of OSF include oral mucosal pallor and mucosal rigidity (Figure 3), which leads to limited opening of the mouth (Figure 4) (3). Consumption of products containing areca nut, such as supari, can play an important role in the onset and progression of OSF and cancerous lesions, and is therefore considered a high-risk behaviors (2, 3). Consumption of products containing areca nut is common in Southeast Asian countries such as India, Bangladesh, and Pakistan (1, 4). In Iran, areca nut consumption is common in cities, such as Chabahar (South East of Iran), that are located near the border with Pakista. There are few epidemiological studies on the consumption of different areca nut products and the associated oral changes in the people of Chabahar (a city where areca nut products are easily available). In this study, which was conducted 2010, 1500 people, 1067 (71.1%) men and 433 (28.9%) women, (with use formulae of sampling size) who attended different health centers in Chabahar city were randomly selected and evaluated for consumption of areca nut products. To our knowledge, this was the first study was done in this field in southeast Iran. Among these subjects, 759 people, including 141 women and 618 men (age range, 8–48 years; mean age, 20–22 years) were found to consume areca nut products (pan, supari, and guthka). The pattern of consumption of these products showed significant gender-based differences (P < 0.05); pan consumption was common among men (391 men, 51.5%), and supari consumption was common among women (135 women; 95.7%). The women in our study believed that supari is beneficial for digestion and chewed

Risk of Betel Nut Chewing: Chemical and Toxicological Studies

Abstract: Last few decades epidemiological reports warn that the development of oral submucous fibrosis − a precancerous state, is universal among betel nut or areca nut users. Betel nut contains arecoline and other microelements which are released into the buccal cavity during the process of areca nut chewing. The present effort was undertaken to find out the correlations between chemical ingredients, like arecoline, magnesium, iron and copper present in betel nut with toxicological incidences in experimental animals. Arecoline was estimated by HPLC (Perkin Elmer, USA) and other micronutrients like magnesium, iron and copper was assessed by AAS (Perkin Elmer, USA). Repeated dose 90-day sub-acute oral toxicity of betel nut water extract (BNE) at the dose of 0.5X10-2 ml/g/day and 1.0X10-2 ml/g/day was performed on Wistar rats as per the Organization for Economic Co-operation and Development (OECD) guidelines No. 408. The result indicates that betel nut contains Group 1 human carcinogen arecoline with significant high level of magnesium, iron and copper. Moreover, consumption of betel nut induces liver damage in rats by indicating significant enhancement of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP). It may conclude that chemical ingredients presences in betel nut are harmful for health and it should be restricted.