Topic
Arecoline
About: Arecoline is a research topic. Over the lifetime, 744 publications have been published within this topic receiving 16015 citations. The topic is also known as: methylarecaiden & methylarecaidin.
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TL;DR: It is suggested that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.
Abstract: In 11-13 month C57BL/6Nnia mice, arecoline produced a dose-dependent decrease in motor activity at doses of 0.64-2.5 mg/kg, whereas at doses of 5.0-20.0 mg/kg arecoline produced a dose-dependent increase in motor activity. In marked contrast, age-matched NZB/B1NJ (New Zealand Black) mice failed to exhibit the first phase of the response, but showed a greater dose-dependent increase in motor activity following the doses of 10 and 20 mg/kg. Nicotine, 0.64-2.5 mg/kg, produced a dose-dependent decrease in motor activity in both strains. The effects of arecoline and nicotine were antagonized by scopolamine (2.5 mg/kg) and mecamylamine (1.0 mg/kg), respectively. These findings suggest that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.
13 citations
TL;DR: An accurate and simple high performance liquid chromatography tandem mass spectrometry method for simultaneous quantification of are coline, arecaidine and arecoline N‐oxide in rat plasma was developed and fully validated to study their pharmacokinetic behaviors in rats.
13 citations
TL;DR: In this study, muscarinic agonism for arecoline series is governed by strict structure-activity relationships, as previously observed for other agonist series.
13 citations
TL;DR: Evidence is provided that central muscarinic receptors are cholinergically innervated (physiologic) while central nicotinic receptors are not cholinergic innervation but are cholinoceptive (pharmacological).
Abstract: The cholinergic innervation of central muscarinic (M-Ch) and nicotinic (N-Ch) receptors was evaluated by studying the interaction of physostigmine with the discriminative stimulus (DS) effects of arecoline and nicotine. Rats were trained to discriminate either arecoline (1.74 mg/kg) or nicotine (1.14 mg/kg) from saline using a two-lever, milk reinforced, operant task. Physostigmine (0.125 mg/kg) pretreatment potentiated, and when administered alone (0.25 mg/kg), generalized with the DS induced by arecoline. In contrast, physostigmine, at the same dose, neither potentiated nor generalized with the DS effects of nicotine. These findings provide evidence that central muscarinic receptors are cholinergically innervated (physiologic) while central nicotinic receptors are not cholinergically innervated but are cholinoceptive (pharmacological).
13 citations
TL;DR: Synthese des composes du titre et en particulier de la piquindone a partir d'arecoline ou d'arrecolone as mentioned in this paper.
Abstract: Synthese des composes du titre et en particulier de la piquindone a partir d'arecoline ou d'arecolone
13 citations