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Astragalus lentiginosus

About: Astragalus lentiginosus is a research topic. Over the lifetime, 32 publications have been published within this topic receiving 941 citations.

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Journal ArticleDOI
09 Apr 1982-Science
TL;DR: In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.
Abstract: The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...

389 citations

Journal ArticleDOI
TL;DR: A survey of the major locoweeds from areas where locoweed poisoning has occurred and found species found to contain the fungal endophyte and produce substantial amounts of swainsonine were A. mollissimus, A. cibarius, and O. sericea.
Abstract: Locoweeds (Astragalus and Oxytropis spp. that contain the toxic alkaloid swainsonine) cause widespread poisoning of livestock on western rangelands. There are 354 species of Astragalus and 22 species of Oxytropis in the US and Canada. Recently, a fungal endophyte, Embellisia spp., was isolated from Astragalus and Oxytropis spp. and shown to produce swainsonine. We conducted a survey of the major locoweeds from areas where locoweed poisoning has occurred to verify the presence of the endophyte and to relate endophyte infection with swainsonine concentrations. Species found to contain the fungal endophyte and produce substantial amounts of swainsonine were A. wootoni, A. pubentissimus, A. mollissimus, A. lentiginosus, and O. sericea. Astragalus species generally had higher concentrations of swainsonine than Oxytropis. Swainsonine was not detected in A. alpinus, A. cibarius, A. coltonii, A. filipes, or O. campestris. The endophyte could not be cultured from A. mollissimus var. thompsonii or A. amphioxys, but was detected by polymerase chain reaction, and only 30% of these samples contained trace levels of swainsonine. Further research is necessary to determine if the endophyte is able to colonize these and other species of Astragalus and Oxytropis and determine environmental influences on its growth and synthesis of swainsonine.

97 citations

Journal ArticleDOI
22 Aug 2012-Botany
TL;DR: Endophytic fungi from Astragalus locoweeds were compared to Undifilum oxytropis isolates obtained from dried plant material of Oxytropis lamberteii from New Mexico and Oxy Tropis sericea from Arizona, Colorado, New Mexico, Utah, and Wyoming.
Abstract: New species of Undifilum, from locoweeds Astragalus lentiginosus Vitman and Astragalus mollissimus Torr., are described using morphological characteristics and molecular phylogenetic analyses as Un...

58 citations

Journal ArticleDOI
TL;DR: Findings suggest several possible reasons for differential concentrations of swainsonine that will be tested in future work, including sequence variants of U. oxytropis that exist within populations of A. mollissimus, A. lentiginosus, and Oxytropis and do not correlate with chemotype.
Abstract: Locoweeds are defined as Astragalus and Oxytropis species that induce locoism due to the toxic alkaloid swainsonine. Swainsonine was detected in all parts of Astragalus lentiginosus and Astragalus ...

46 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20192
20172
20151
20121
20111
20101