Topic
Atmospheric-pressure chemical ionization
About: Atmospheric-pressure chemical ionization is a research topic. Over the lifetime, 3770 publications have been published within this topic receiving 120817 citations.
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TL;DR: In this paper, the phenolic component of freeze-dried olive fruit was fractionated by high-performance liquid chromatography using ultraviolet, atmospheric pressure chemical ionisation (APCI) and electrospray ionization (ESI) detection.
1,221 citations
TL;DR: Results point to changes in the droplet solution properties caused by the presence of nonvolatile solutes as the main cause of ionization suppression in electrospray ionization of biological extracts.
1,012 citations
TL;DR: In this article, a method for analyzing a sample of an analyte provided as a sample solution comprising a solvent and a dopant is provided, either separately or as the solvent of the sample solution.
Abstract: There is provided a method of, and apparatus for, analyzing a sample of an analyte provided as a sample solution comprising a solvent and an analyte. A dopant is provided, either separately or as the solvent of the sample solution. The sample solution is formed into a spray, for example in a nebulizer, and the solvent evaporated. The sample stream is irradiated in a region at atmospheric pressure, either in the liquid state prior to formation of a spray, or in the liquid state after formation of a droplet spray, or in the vapour state after evaporation of the sprayed droplets, to ionize the dopant. Then, subsequent collisions between the ionized dopant and the analyte, either directly or indirectly, result in ionization of the analyte. Analyte ions are passed from the atmospheric pressure ionization region into a mass analyzer for mass analysis. This technique has been found to give much enchanced inonization for some substances, as compared to atmospheric pressure chemical ionization.
761 citations
TL;DR: Improvements have occurred in IMS on the understanding of reagent gas chemistries, the influence of temperature on ion stability, and sampling methods, and commercial instruments have been refined to provide fast and reliable measurements for on-site detection of explosives.
709 citations
638 citations