Topic
Autolysosome
About: Autolysosome is a research topic. Over the lifetime, 383 publications have been published within this topic receiving 37686 citations.
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Patent•
21 May 2019
TL;DR: In this paper, the authors showed that the use of lithospermic acid has a significant inhibition effect on the expression of hepatitis B virus (HBV) DNA and hepatitis b virus e antigen (HBeAg) in a dose-dependent manner.
Abstract: The invention discloses application of lithospermic acid in preparing anti-hepatitis-B-virus drugs, and belongs to the field of pharmacy. It is shown through cell test results that the lithospermic acid has a significant inhibition effect on the expression of hepatitis B virus (HBV) DNA and hepatitis B virus e antigen (HBeAg) in a dose-dependent manner, so that the lithospermic acid has anti-HBV activity. The lithospermic acid can promote the formation of autophagosome and the degradation of autolysosome, and the anti-HBV molecular mechanism of the lithospermic acid is that the HBV-induced incomplete autophagy process is interfered with by promoting the complete autophagy of hepatocytes, and therefore the replication of HBVs is inhibited. The results indicate that the lithospermic acid hasthe good inhibition effect on the HBVs and has a potential for preparing drugs for resisting hepatitis B and other related diseases.
01 Jan 2020
TL;DR: In this article, the authors proposed targeting the genes of stage-specific regulation of autophagy could be a novel approach for the directive suppression and prevention of cancer, and also developed drugs which specifically acts upon the cancer cells and modulate the autophagocytosis process.
Abstract: Autophagy is a highly conserved metabolic process to degrade cytoplasmic materials, damaged organelles and aggregated milieus through formation of autolysosome with the help of lysosomal acid hydrolases. This multistep event has a dual role in the regulation of cancer. The termination step of autophagy involving fusion of autophagosome and lysosome degrades autopahgic cargo to establish the cellular homeostasis. This is the point which defines the cytoprotective nature of autophagy in some cases and on the contrary, it also acts as tumor suppressor step due to accumulation of autophagic vacuoles or excessive autopahgic flux in most of the cancers. In this setting, many different drugs have been developed and discovered to combat the various type of cancers through the modulation of autophagy in the cancer cells either by its activation or suppression mechanism. Interestingly, targeting the genes of stage-specific regulation of autophagy could be a novel approach for the directive suppression and prevention of cancer. Moreover, the endocytosis–autophagy crosstalk gives an edge to develop drugs which specifically acts upon the cancer cells and modulate the autophagy process. In addition, the drugs modulating the fusion step of autophagy may be the novel molecule for the cancer therapeutics which needs to be investigated further for future cancer treatment.
Patent•
11 Mar 2015
TL;DR: In this paper, a complex composed of an organic compound ligand and a metal ion is used as an autolysosome hydrogen peroxide marker, which can be used as the marker of hydrogen peroxidation in an autophagic process.
Abstract: The invention relates to a complex which is composed of an organic compound ligand and a metal ion and is used as an autolysosome hydrogen peroxide marker. The complex can be used as the marker of hydrogen peroxide in an autolysosome for detecting the content of the hydrogen peroxide during an autophagic process, and especially relates to lysosome diseases, such as detection and monitoring of an accumulation process of the hydrogen peroxide in lysosome, and monitoring of diseases relative to the hydrogen peroxide in lysosome. The invention also relates to a toxin screening method, especially relates to a screening method and high-throughput screening of potential drugs and suspicious toxic substances. The marker also can be used in experiments and tissue imaging on the basis of a fluorescent microscope and a confocal microscopy.