Topic
Bacteria
About: Bacteria is a research topic. Over the lifetime, 23676 publications have been published within this topic receiving 715990 citations. The topic is also known as: eubacteria.
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01 Jan 1995
TL;DR: Characteristics and Activities of Sulfate-reducing Bacteria L.M. Tomei, and Molecular Biology of Redoxactive Metal Proteins from Desulfovibrio W.D. van Dongen.
Abstract: Characteristics and Activities of Sulfate-reducing Bacteria L.L. Barton, F.A. Tomei. Sulfate-reducing Archaea R.K. Thauer, J. Kunow. Taxonomic Relationships E. Stackebrandt, et al. Respiratory Sulfate Reduction J.M. Akagi. Characteristics of Electron Transfer Proteins L. Chen, et al. Solute Transport and Cell Energetics H. Cypionka. Molecular Biology of Redoxactive Metal Proteins from Desulfovibrio W.M.A.M. van Dongen. Ecology of Sulfate-reducing Bacteria G.D. Fauque. Biocorrosion W.A. Hamilton, W. Lee. Control in Industrial Settings T.R. Jack, D.W.S. Westlake. Metabolism of Environmental Contaminants by Mixed and Pure Cultures of Sulfate-reducing Bacteria B.D. Ensley, J.M. Suflita. Index.
349 citations
TL;DR: In silico analysis of various mycobacterial genomes, results indicate that Pks13 is the condensase, a promising target for the development of new antimicrobial drugs against Corynebacterineae.
Abstract: Mycolic acids are major and specific constituents of the cell envelope of Corynebacterineae, a suborder of bacterial species including several important human pathogens such as Mycobacterium tuberculosis, Mycobacterium leprae, or Corynebacterium diphtheriae. These long-chain fatty acids are involved in the unusual architecture and impermeability of the cell envelope of these bacteria. The condensase, the enzyme responsible for the final condensation step in mycolic acid biosynthesis, has remained an enigma for decades. By in silico analysis of various mycobacterial genomes, we identified a candidate enzyme, Pks13, that contains the four catalytic domains required for the condensation reaction. Orthologs of this enzyme were found in other Corynebacterineae species. A Corynebacterium glutamicum strain with a deletion in the pks13 gene was shown to be deficient in mycolic acid production whereas it was able to produce the fatty acids precursors. This mutant strain displayed an altered cell envelope structure. We showed that the pks13 gene was essential for the survival of Mycobacterium smegmatis. A conditional M. smegmatis mutant carrying its only copy of pks13 on a thermosensitive plasmid exhibited mycolic acid biosynthesis defect if grown at nonpermissive temperature. These results indicate that Pks13 is the condensase, a promising target for the development of new antimicrobial drugs against Corynebacterineae.
348 citations
TL;DR: It is suggested that the isolated acid- and bile-tolerant isolates possess growth advantages over that of the parents under stress conditions and may be considered as candidates for probiotic strains after further characterization with animal models.
347 citations
TL;DR: This investigation compared the antibacterial effects of amalgam, zinc oxide-eugenol, Super EBA and a mineral trioxide aggregate on nine facultative bacteria and nine strict anaerobic bacteria.
347 citations
TL;DR: The enzymes which catalyze the oxidation of ammonia to nitrite by autotrophic bacteria are reviewed and a comparison is made with enzymes which catalyst the same reactions in methylotrophs and organotrophic heterotrophicacteria.
Abstract: The enzymes which catalyze the oxidation of ammonia to nitrite by autotrophic bacteria are reviewed. A comparison is made with enzymes which catalyze the same reactions in methylotrophs and organotrophic heterotrophic bacteria.
345 citations