Topic
Baicalein
About: Baicalein is a research topic. Over the lifetime, 1819 publications have been published within this topic receiving 50783 citations. The topic is also known as: 5,6,7-trihydroxyflavone.
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TL;DR: This review is aimed to summarize the research results obtained since the last 20 years and to highlight the recently discovered molecular mechanisms of Scutellaria baicalensis.
747 citations
TL;DR: In this paper, the free radical scavenging and antioxidant properties of the four major flavonoids in the radix of Scutellaria baicalensis Georgi were examined in different systems.
580 citations
TL;DR: Evidence of anticancer properties of orange juice and indicate that citrus flavonoids are effective inhibitors of human breast cancer cell proliferation in vitro are provided, especially when paired with quercetin, which is widely distributed in other foods.
Abstract: Two citrus flavonoids, hesperetin and naringenin, found in oranges and grapefruit, respectively, and four noncitrus flavonoids, baicalein, galangin, genistein, and quercetin, were tested singly and in one‐to‐one combinations for their effects on proliferation and growth of a human breast carcinoma cell line, MDA‐MB‐435. The concentration at which cell proliferation was inhibited by 50% (IC50), based on incorporation of [3H]thymidine, varied from 5.9 to 140 μg/ml for the single flavonoids, with the most potent being baicalein. IC50 values for the one‐to‐one combinations ranged from 4.7 μg/ml (quercetin + hesperetin, quercetin + naringenin) to 22.5 μxglml (naringenin + hesperetin). All the flavonoids showed low cytotoxicity (>500 μg/ml for 50% cell death). Naringenin is present in grapefruit mainly as its glycosylated form, naringin. These compounds, as well as grapefruit and orange juice concentrates, were tested for their ability to inhibit development of mammary tumors induced by 7,12‐dimethylbe...
501 citations
TL;DR: Flavonoids of the flavone, flavonol, flavanone, and isoflavone classes possess antiproliferative effects in different cancer cell lines.
Abstract: Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Their proposed protective role in tumor development may prevail especially in the intestinal tract due to direct exposure of intestinal epithelia to these dietary ingredients. We have screened more than 30 flavonoids for their effects on cell proliferation and potential cytotoxicity in the human colon cancer cell lines Caco-2, displaying features of small intestinal epithelial cells, and HT-29, resembling colonic crypt cells. In addition, for selected compounds we assessed whether they induce apoptosis by determining caspase-3 activation. Studies on the dose dependent effects of the flavonoids showed antiproliferative activity of all compounds with EC50 values ranging between 39.7 ± 2.3 μM (baicalein) and 203.6 ± 15.5 μM (diosmin). In almost all cases, growth inhibition by the flavonoids occured in the absence of cytotoxicity. There was no obvious structure-activity relationship in the antiproliferative effects either on basis of the subclasses (i.e., isoflavones, flavones, flavonols, flavanones) or with respect to kind or position of substituents within a class.
471 citations
TL;DR: It is shown here that low micromolar concentrations of baicalein, and especially its oxidized forms, inhibit the formation of α-synuclein fibrils and that diets rich in flavonoids may be effective in preventing the disorder.
416 citations