scispace - formally typeset
Search or ask a question
Topic

Benzofuran

About: Benzofuran is a research topic. Over the lifetime, 3943 publications have been published within this topic receiving 47930 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: A general method for copper-catalyzed arylation of sp (2) C-H bonds with p K a's below 35 has been developed and two arylcopper-phenanthroline complex intermediates were independently synthesized.
Abstract: A general method for copper-catalyzed arylation of sp2 C−H bonds with pKaʼs below 35 has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide or K3PO4 base, and DMF, DMPU, or mixed DMF/xylenes solvent. A variety of electron-rich and electron-poor heterocycles such as azoles, caffeine, thiophenes, benzofuran, pyridine oxides, pyridazine, and pyrimidine can be arylated. Furthermore, electron-poor arenes possessing at least two electron-withdrawing groups on a benzene ring can also be arylated. Two arylcopper−phenanthroline complex intermediates were independently synthesized.

520 citations

Journal ArticleDOI
TL;DR: The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described and the reaction is shown to take place in both inter- and intramolecular scenarios.
Abstract: The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described. The reaction is shown to take place in both inter- and intramolecular scenarios.

419 citations

Journal ArticleDOI
TL;DR: The present review is endeavour to highlight the progress in the various pharmacological activities of benzofuran derivatives in the current literature with an update of recent research findings on this nucleus.
Abstract: In nature's collection of biologically active heterocycles, benzofuran derivatives constitute a major group. The broad spectrum of pharmacological activity in individual benzofurans indicates that this series of compounds is of an undoubted interest. Benzofuran and its derivatives have attracted medicinal chemists and pharmacologists due to their pronounced biological activities and their potential applications as pharmacological agents. Due to the wide range of biological activities of benzofurans, their structure activity relationships have generated interest among medicinal chemists, and this has culminated in the discovery of several lead molecules in numerous disease conditions. The outstanding development of benzofuran derivatives in diverse diseases in very short span of time proves its magnitude for medicinal chemistry research. The present review is endeavour to highlight the progress in the various pharmacological activities of benzofuran derivatives in the current literature with an update of recent research findings on this nucleus.

363 citations

Journal ArticleDOI
TL;DR: In this paper, the conversion of furan (a model of cellulosic biomass) over HZSM-5 was investigated in a thermogravimetric analysis-mass spectrometry system, in situ Fourier transform infrared analysis, and in a continuous flow fixed-bed reactor.
Abstract: The conversion of furan (a model of cellulosic biomass) over HZSM-5 was investigated in a thermogravimetric analysis–mass spectrometry system, in situ Fourier transform infrared analysis, and in a continuous-flow fixed-bed reactor. Furan adsorbed as oligomers at room temperature with a 1.73 of adsorbed furan/Al ratio. These oligomers were polycyclic aromatic compounds that were converted to CO, CO2, aromatics, and olefins at temperatures from 400 to 600 °C. Aromatics (e.g., benzene, toluene, and naphthalene), oligomer isomers (e.g., benzofuran, 2,2-methylenebisfuran, and benzodioxane), and heavy oxygenates (C12+ oligomers) were identified as intermediates formed inside HZSM-5 at different reaction temperatures. During furan conversion, graphite-type coke formed on the catalyst surface, which caused the aromatics and olefins formation to deactivate within the first 30 min of time on-stream. We have measured the effects of space velocity and temperature for furan conversion to help us understand the chemist...

299 citations

Journal ArticleDOI
TL;DR: The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C-H bond cleavage to give the corresponding 3-vinylated products.
Abstract: The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C−H bond cleavage to give the corresponding 3-vinylated products. Similarly, benzothiophene-, benzofuran-, pyrrole-, and indolecarboxylic acids also undergo regioselective vinylation.

262 citations


Network Information
Related Topics (5)
Aryl
95.6K papers, 1.3M citations
91% related
Carboxylic acid
48.5K papers, 605.6K citations
91% related
Moiety
40K papers, 615K citations
91% related
Pyridine
39.7K papers, 561.9K citations
91% related
Nucleophile
30.8K papers, 602.8K citations
90% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202375
2022162
2021101
2020125
2019152
2018138