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Benzoic acid

About: Benzoic acid is a research topic. Over the lifetime, 11832 publications have been published within this topic receiving 167127 citations. The topic is also known as: Retardex & E210.


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Journal ArticleDOI
TL;DR: An efficient and practical synthetic method for the functionalized 2-pyrrolidinones was successfully developed via the domino reactions of ethyl glyoxylate and acetylenedicarboxylate with 2-M arylamines in the presence of benzoic acid as catalyst as mentioned in this paper.

47 citations

Journal ArticleDOI
TL;DR: The low toxicity-high Fe mobilization efficacy of selected adamantane-based DFOB conjugates underscores the potential of these compounds to treat iron overload disease in patients with transfusional-dependent disorders such as beta-thalassemia.
Abstract: Desferrioxamine B (DFOB) conjugates with adamantane-1-carboxylic acid, 3-hydroxyadamantane-1-carboxylic acid, 3,5-dimethyladamantane-1-carboxylic acid, adamantane-1-acetic acid, 4-methylphenoxyacetic acid, 3-hydroxy-2-methyl-4-oxo-1-pyridineacetic acid (N-acetic acid derivative of deferiprone), or 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid (deferasirox) were prepared and the integrity of Fe(III) binding of the compounds was established from electrospray ionization mass spectrometry and RP-HPLC measurements. The extent of intracellular 59Fe mobilized by the DFOB-3,5-dimethyladamantane-1-carboxylic acid adduct was 3-fold greater than DFOB alone, and the IC50 value of this adduct was 6- or 15-fold greater than DFOB in two different cell types. The relationship between logP and 59Fe mobilization for the DFOB conjugates showed that maximal mobilization of intracellular 59Fe occurred at a logP value ∼2.3. This parameter, rather than the affinity for Fe(III), appears to influence the extent of i...

47 citations

Journal ArticleDOI
TL;DR: The vanadium complex catalyzes the oxidation of styrenes with hydrogen peroxide in air to give aldehydes, ketones, and carboxylic acids as mentioned in this paper, and the reaction begins with H2O2 coordination to the vanadium ion followed by the formation of hydroxyl radicals.
Abstract: The vanadium complex—pyrazine-2-carboxylic acid (PCA) system catalyzes oxidation of styrenes PhRC=CHR′ (R=H, Me; R′=H, Ph), or phenylacetylenes PhC=CR (R=H, Ph) with hydrogen peroxide in air to give aldehydes, ketones, and carboxylic acids. The reaction begins with H2O2 coordination to the vanadium ion followed by the formation of hydroxyl radicals. Catalytic action of PCA facilitates the reduction of the VV complex to the VIV complex and/or the stage of the formation of a peroxide derivative of vanadium.

47 citations

Journal ArticleDOI
01 Apr 1990-Langmuir
TL;DR: In this paper, surface-enhanced Raman scattering (SERS) has been observed from a model acrylic adhesive deposited onto silver island films, indicating that the observed Raman signal was characteristic of the interface and not of the bulk of the films.
Abstract: : Surface-enhanced Raman scattering (SERS) has been observed from a model acrylic adhesive deposited onto silver island films. SERS spectra of the adhesive system were very similar to SERS spectra of o-benzoic sulphimide (saccharin), a component of the curing system of the adhesive, and to normal Raman spectra of the sodium salt of saccharin. When saccharin was replaced in the curing system by benzoic acid, SERS spectra of the adhesive were similar to SERS spectra of benzoic acid and to normal Raman spectra of benzoic acid salts. The intensity of the SERS spectra was independent of the thickness of the adhesive films, indicating that the observed Raman signal was characteristic of the interface and not of the bulk of the films. These results demonstrate that saccharin and benzoic acid wee preferentially adsorbed at the silver surface to form metal salts and that surface-enhanced Raman scattering can be used for non- destructive characterization of interphases between polymer films and SERS- active metal substrates as long as the films are not so thick that normal Raman scattering from the bulk is comparable in intensity to the SERS from the interphase.

46 citations

Journal ArticleDOI
TL;DR: In this paper, the culture conditions of Polyporus tuberaster K2606 were investigated to find conditions with which much benzaldehyde and benzyl alcohol would be obtained in high yield.
Abstract: The culture conditions of Polyporus tuberaster K2606 were investigated to find conditions with which much benzaldehyde and benzyl alcohol would be obtained. Strain K2606 reduced benzoic acid as well as L-phenylalanine to benzaldehyde and benzyl alcohol in high yield. The conversion rate of benzoic acid was about 60%. Two other metabolites of L-phenylalanine, 3-phenylpropionic acid and 3-phenylpyruvic acid, were reduced to benzaldehyde and benzyl alcohol as well. Veratryl alcohol, a secondary metabolite of L-phenylalanine, was not detected. Benzaldehyde produced by strain K2606 was reduced to benzyl alcohol, which was slowly converted again into benzaldehyde when culture with shaking continued

46 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023207
2022519
2021217
2020279
2019315
2018332