Topic
Benzophenone
About: Benzophenone is a research topic. Over the lifetime, 5318 publications have been published within this topic receiving 74597 citations. The topic is also known as: Benzoylbenzene & Diphenyl ketone.
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152 citations
TL;DR: The "forbidden" and excitation-activated world of photoinduced covalent attachment of BP photophores is explored by touring a colorful palette of recent examples, and it is hoped that both novice and expert photolabelers will be inspired by the breadth and depth of possibilities.
Abstract: The widespread applications of benzophenone (BP) photochemistry in biological chemistry, bioorganic chemistry, and material science have been prominent in both academic and industrial research. BP photophores have unique photochemical properties: upon n−π* excitation at 365 nm, a biradicaloid triplet state is formed reversibly, which can abstract a hydrogen atom from accessible C–H bonds; the radicals subsequently recombine, creating a stable covalent C–C bond. This light-directed covalent attachment process is exploited in many different ways: (i) binding/contact site mapping of ligand (or protein)–protein interactions; (ii) identification of molecular targets and interactome mapping; (iii) proteome profiling; (iv) bioconjugation and site-directed modification of biopolymers; (v) surface grafting and immobilization. BP photochemistry also has many practical advantages, including low reactivity toward water, stability in ambient light, and the convenient excitation at 365 nm. In addition, several BP-conta...
150 citations
149 citations
TL;DR: Sorbic acid (trans,trans-hexadienoic acid) was developed as a probe for the quantification of the formation rate, overall solution scavenging rate and steady-state concentrations of triplet-excited states of organic compounds.
148 citations