Showing papers on "Benzopyran published in 1977"

Synthesis of some benzopyran derivatives related to the seed germination stimulant of Orobanche crenata. I. 3,3a,4,9b-Tetrahydro-2H-furo[3,2-c][l]benzopyrans

Abstract: The furobenzopyran derivatives (1a) and (1b) have been prepared by a simple route from m-methoxy-phenol.

Synthesis and structure-activity relations of 5H,11H-[2]benzopyrano[4,3-g][1]benzopyran-9-carboxylic acids

Abstract: The synthesis and properties of the title compounds 1 are described. Many of these compounds are potent inhibitors of the passive cutaneous anaphylaxis reaction of rats against egg albumin challenge. Structural variations include substitutions in the 2, 3, 4, 5, 7, and 12 position of the nucleus 1. A novel rearrangement from a compound of the related [3,4-f] series to this group is reported.

Reactions of 6a,11a-dihydro-6H-benzofuro[3,2-c]benzopyran

Abstract: Lead(IV) acetate was found to be a suitable dehydrogenating agent for the preparation of 6H-benzofuro[3,2-c]benzopyran from its 6a,11a-dihydro-derivative. The product was also synthesised independently. A scheme for the chemical interconversion of the 6H-benzofuro[3,2-c]benzopyrans and the related isoflavonoids is suggested.

[(4-Oxo-4H-1-benzopyran-3-yl)oxy] acetic acids and derivatives

Abstract: Compounds of formula I: ##STR1## wherein Y is hydrogen, lower alkyl, halogen or lower alkoxy; X is carboxy, alkoxycarbonyl, carboxamide, cyano or tetrazolo, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthmatic reactions.

7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid

Abstract: The invention relates to synthetic processes to produce the known pharmacologically active 9-methoxypsoralen. Also disclosed are various novel intermediates utilized in these processes.

Method of lowering blood lipid levels in mammals

Abstract: Levels of lipids in the blood of mammals are lowered by certain benzodioxin and benzopyran carboxamides.

Further studies on the structural determination of esters of 4‐oxo‐4h‐1‐benzopyran‐2‐carboxylic acids using the paramagnetic shift reagent eu(fod)3

Abstract: The effect of Eu(fod)3 on the signals of benzylic ruethvlene protons in the pmr spectra of 4-oxo-4H-1-benzopyran derivatives is described. Assignments were confirmed by decoupling experiments. The technique provides a method for distinguishing between structural isomers.

Analgesic benzopyran ester prepn. - from a homopiperidino-alkanoic acid with a cycloalkano-benzopyran deriv

Abstract: New benzopyran esters of formula (I) and their acid addn. salts. In formula (I), R is H or 1-6C alkyl; R1 is 1-6C alkyl; R2 is 1-20C alkyl; R3 is a gp. of formula (Ia) in which m is 0-8 and R4 is H or 1-6C alkyl; and n is 3-7. Specific cpds. (I) include 4,4-dimethyl-9-/4-(homopiperidino)-butyryloxy/-7-(3-methyl-2-octy- l)-1,2,3,4-tetrahydrocyclopenta c 1 benzopyran. In an example, (I) is prepd. by reacting 4,4-dimethyl-9-hydroxy-7-(3-methyl-2-octyl)-1,2,3,4-tetrahydrocyc- lopenta c 1 benzopyran (1.7 g.) with 4-homopiperidinobutyric acid hydrochloride (1.10 g.) in CH2Cl2 (200 ml.) in the presence of dicyclohexylcarbodiimide (1.13 g.). The prod. is isolated as the hydrochloride (1.7 g; m.pt. 147-9 degrees. (I) are useful as analgesics, minor tranquillisers and anticonvulsants. When tested in the tail-flick and hit-plate tests, (I) show analgesic activity at doses of 20-40 mg./kg. p.o. and 10-20 mg./kg. i.p. In mice, (I) show minor tranquilliser activity at doses of 5-40 mg./kg. i.p.; activity is seen in dogs at 1-5 mg./kg. Anticonvulsant activity is observed in mice at doses of 1-5 mg./kg. p.o. and in rates at 5-10 mg./kg. p.o.