Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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8 citations
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8 citations
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TL;DR: In this paper, the conformation of the dihydropyran ring and the chemical shift differences in the pairs of isomeric adducts are discussed, as well as the properties of these products and related compounds.
Abstract: Reaction of 1′,3′,3′-trimethylspiro[2H-1-benzopyran-2,2′-indolines] with 1,1-bis[4-(dimethylamino)phenyl]ethylene can give two types of isomeric products, 2,2-bis[4-(dimethylamino)-phenyl]-4-{2-methylidene-1,3,3-trimethylindoline}chromans (2a–e) and 1′,3′,3′-trimethyl-4-{2,2-bis[4-(dimethylamino)phenyl]vinyl}-spiro[chroman-2,2′-indolines] (3a–d).
These products and related compounds have been analysed by spectroscopic methods. The conformation of the dihydropyran ring and the chemical shift differences in the pairs of isomeric adducts are discussed.
8 citations
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TL;DR: A new series of 3,4‐dihydro‐3‐amino‐2H‐1‐benzopyran derivatives bearing various substituents on the 5‐position was successfully prepared via palladium‐mediated cross‐coupling reactions and some of the new compounds showed high affinity for 5‐HT1A and5‐HT7 receptors.
Abstract: A new series of 3,4-dihydro-3-amino-2H-1-benzopyran derivatives (1 and 2) bearing various substituents on the 5-position was successfully prepared via palladium-mediated cross-coupling reactions. Some of the new compounds showed high affinity for 5-HT1A and 5-HT7 receptors. The best affinity for the 5-HT1A and 5-HT7 receptors was obtained for 2b (Ki = 0.3 nM for 5-HT1A and 3.1 nM for 5-HT7). The anxiolytic activity of compound 2b was evaluated.
8 citations