Benzopyran

About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.

Novel benzopyran derivatives

Abstract: Compounds of the Formula: ##STR1## wherein: R1-7 are as defined in the specification. The compounds and salts exhibit useful pharmacological properties, including potassium channel activating properties and 5-lipoxygenase inhibiting properties, and in particular are useful as smooth muscle relaxants and bronchodilators.

An elegant synthesis of 2,2-dimethyl-2H,5H-pyrano[3,2-c] [1] benzopyran-5-ones

Abstract: Les composes du titre sont obtenus par condensation d'hydroxy-4 coumarines avec l'isoprene suivie de deshydrogenation avec le DDQ; obtention egalement par cette condensation de dimethyl-2,2 tetrahydro-2,3,4,5 pyranno [2,3-b] benzopyranne-1ones-5

Benzopyrane derivatives, process for their preparation and pharmaceutical compositions containing them

Abstract: Benzopyran derivs of formula (I), their isomers and acid addn salts, are new n = 1 or 2; R1 = H, 1-6C alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridine-methyl, pyridine-aminocarbonyl, phthalimido(1-6C)alkyl, (thiochroman-8-yl-oxy)-(1-4C)alkyl, (benzo-dioxanyl-oxy)(1-4C)alkyl, acylamino(1-6C)alkyl; acyl (in acylamino) = benzoyl, naphthylcarbonyl, thienylcarbonyl, (1-6C)alkyl-carbonyl, furylcarbonyl, pyrrolylcarbonyl, pyridinylcarbonyl or (3-7C)cycloalkylcarbonyl, all opt substd by one or more halo, trihalomethyl, alkoxy or hydroxy; R2, R3, R4 = H, halo, (1-6C)alkyl, (1-6C)alkoxy, hydroxy, acetyl, aminocarbonyl, aminomethyl, cyano, nitro, amino; phenyl opt substd by one or more halo, hydroxy, (1-6C)alkoxy, (1-6C)alkyl or trihalomethyl; furyl, pyridinyl, thienyl or pyrrolyl; or R2+R3 on adjacent C atoms form furan or phenyl

Synthesis of Some 4-[3′ or 4′-(4H-4-Oxo-1-benzopyran-2-yl)phenyl]-1,4-dihydropyridine Derivatives as Potential Calcium Channel Antagonists.

Abstract: In this study, the synthesis of new flavonoid derivatives, which possess a 1,4-dihydropyridine (1,4-DHP) moiety on the phenyl ring of flavone were realized. 3' or 4'-Formyl-flavones were synthesized, then the aldehyde groups of these compounds were converted to the 1,4-DHP moiety by the Hantzsch method. A series of 23 new derivatives having different substituents at C-3 and C-5 of the 1,4-DHP ring were prepared. Two compounds (8a, 8b) were tested for their calcium channel blocker activity and 8b exhibited the best result.