Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
Papers published on a yearly basis
Papers
More filters
••
6 citations
•
6 citations
•
05 Feb 2014
TL;DR: In this article, a preparation method of a chiral spiro naphthoquinone benzopyran hydroxyindole compound has been proposed, which can be used for preparing intermediates of chiral drugs and has wide physiological and pharmacological activities.
Abstract: The invention discloses a preparation method of a chiral spiro naphthoquinone benzopyran hydroxyindole compound. The method comprises the following specific steps: reacting the condensation product of an isatin compound and propane dinitrile and a 2-hydroxyl-1,4-naphthoquinone compound in a solvent under the catalysis of quinine thiourea dihydride, thereby obtaining a product. According to the method, raw materials are simple and easily available, the reaction condition is mild, the post-treatment is simple and convenient, the applicative substrates are wide, the enantioselectivity is high, and the yield can reach 99%; therefore, the method is a novel method capable of efficiently synthesizing the chiral spiro naphthoquinone benzopyran hydroxyindole compound having important medicinal value and asymmetric synthesis value. The compound prepared by the method can be used for preparing intermediates of chiral drugs and has wide physiological and pharmacological activities.
6 citations
••
6 citations
••
TL;DR: In this article, a 2.2-formyl-4,4-dimethylcyclohexa-2,5-dien-1-one undergoes hetero-Diels-Alder reactions with electron-rich olefins to yield 3-substituted-5,5dimethyl-3,4, 4a,5tetrahydro-8H-2-benzopyrane-8-ones.
6 citations