Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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10 Feb 1994TL;DR: Spirocycles of general structural formula (I) or a pharmaceutically acceptable salt, hydrate or crystal form thereof (II) which are Class III antiarrhythmic agents as mentioned in this paper.
Abstract: Spirocycles of general structural formula (I) or a pharmaceutically acceptable salt, hydrate or crystal form thereof wherein: R1 = H3CSO2NH-, H3CO-, alkylSO2-, alkylCONH-, NO2-; R2 = H, -OCH?3?; R?3 and R4? taken together are =O; or R3 = H and R4 = OH; R5 = R6 taken together are -CH?2?-CH2- or =CH2; R?7? is (II) which are Class III antiarrhythmic agents.
5 citations
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TL;DR: In this article, various heteroaryls were found to undergo 1,4-oxygen to nitrogen migration (e.g. 4→1) under acidic conditions, which provides a convenient access to 4-(N-alkyl-N-heteroaryl)amino-3, 4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile derivatives, which are otherwise difficult to prepare.
5 citations
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TL;DR: In this article, the chromone 2A (X = H(A), Me(B), Cl(C)) gives a mixture of the dihydropyridine 4A and pyranopyridine 15A, 2B gives 4B, and 2C gives varying amounts of the substituted enamine 3C, pyridone 4Cand benzophenone 8.
Abstract: With ethyl (3-aminocrotonate, the chromone 2A (X = H(A), Me(B), Cl(C)) gives a mixture of the dihydropyridine 4A and pyranopyridine 15A, 2B gives 4B, and 2C gives varying amounts of the substituted enamine 3C, pyridone 4Cand benzophenone 8. 5-Hydroxy-5H-[1]benzopyrano-[4,3-b]pyridine 11 (< 3%) was obtained in each case. Palladised charcoal dehydrogenates dihydropyridines 4A and 4B to respectively 12A and 12B and ammonia converts 12A into the diazanaphthalene 13.
5 citations
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20 May 1987
TL;DR: Transbenzopyran-4,3b-1,4oxazines of the formula TBN are presynaptic dopamine agonists and may be used in pharma-ceutical composition form for treating psychoses, e.g., schizophrenia as discussed by the authors.
Abstract: Trans-benzopyran-4,3b-1,4-oxazines of the formula
wherein R is hydrogen, alkyl or aryl alkyl; X is hydroxy, alkyl, alkoxy, halogen, or benzyloxy. The compounds are presynaptic dopamine agonists and may be used in pharmaceutical composition form for treating psychoses, e.g., schizophrenia.
5 citations
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TL;DR: In this article, the very reactive α-oxo-thioketone derivatives 2a - d, generated via thermolysis of spirobenzopyran-3',2-[1,3,4]oxadithiino[5,6-c]benzopsopyrans-4'-ones 1a-d, reacted with 2,3-dimethyl-1, 3-butadiene and 1,3cyclohexadiene under [4+2]-cycloaddition to afford spiro benzop
Abstract: The very reactive α-oxo-thioketone derivatives 2a - d, generated via thermolysis of spirobenzopyran-3',2-[1,3,4]oxadithiino[5,6-c]benzopyran-4'-ones 1a - d, reacted with 2,3-dimethyl-1,3-butadiene and 1,3-cyclohexadiene under [4+2]-cycloaddition to afford spirobenzopyran-3',6-thiapyran-4'-one adducts 3a-d and spirobenzopyran-3',3-thiabicyclo[2.2.2]oct-5-en-4'-one adducts 4a-d, respectively. On the other hand, the reaction of α-oxo-thioketones 2a-d with isoprene afforded regioselectively only 3-methyl-thiapyran derivatives 5a-d. Single crystal X-ray diffraction studies of 4b, 4c, and 5a give a good support for the established structure.
5 citations