Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
Papers published on a yearly basis
Papers
More filters
•
25 Jul 1991TL;DR: A benzopyran derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and an ACAT inhibitor, an antihyperlipemic agent and an antiarteriosclerotic composition each containing the same as the active ingredient.
Abstract: A benzopyran derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and an ACAT inhibitor, an antihyperlipemic agent and an antiarteriosclerotic composition each containing the same as the active ingredient; formula (I) wherein one of X and Y represents the group (1) and the other of X and Y and R?1 to R10? represent each a substituent.
4 citations
•
14 Feb 2004
TL;DR: In this article, a method for preparing the compound of the formula(I) comprises reacting epoxide compounds of formula(II) with imidazole containing secondary amine compounds, in the presence of metal salt and a solvent.
Abstract: PURPOSE: Benzopyran derivatives substituted by secondary amine containing imidazole and a method for preparing the same are provided. The compounds are useful for treatment of cancer, diabetic retinopathy and external brain wound. CONSTITUTION: Benzopyran derivatives substituted by secondary amine containing imidazole represented by the formula(1), partial stereo isomers thereof and pharmaceutically acceptable salts thereof are provided, wherein R1 is H, CN, NO2 or NH2; R2 is CH3, CHORaRa or CHOOZ; Ra is C1-C4 linear or branched chain alkyl; Z is C2-C6 linear or branched chain alkyl; R3 and R4 are independently H, Cl, Br, F, C1-C3 linear or branched chain alkyl, ORb, CF3, OCF3, NO2 or CO2Rb; Rb is H or C1-C3 alkyl; and * is chiral carbon. A method for preparing the compound of the formula(I) comprises reacting epoxide compounds of the formula(II) with imidazole containing secondary amine compounds of the formula(III) in the presence of metal salt and a solvent, wherein the metal salt is selected from Mg(ClO4)2, COCl2, LiClO4, NaClO4, CaCl2, ZnCl2, LiBF4 and Zn(Tf)2; and the solvent is selected from acetonitrile, tetrahydrofuran and dimethylformamide.
4 citations
••
4 citations
••
TL;DR: Total syntheses of teadenols A and B, isolated from fermented tea, were accomplished in a highly stereocontrolled manner, utilizing the different conformational preferences of cyclic and acyclic carbonate precursors to obtain cis- and trans-fused benzopyran rings, respectively, via intramolecular etherification.
Abstract: Total syntheses of teadenols A and B, isolated from fermented tea, were accomplished in a highly stereocontrolled manner. Key steps were an organocatalytic asymmetric α-aminoxylation reaction of an aldehyde and a palladium-catalyzed intramolecular allylic substitution with phenol. In the latter reaction, we utilized the different conformational preferences of cyclic and acyclic carbonate precursors to obtain cis- and trans-fused benzopyran rings, respectively, via intramolecular etherification.
4 citations
••
4 citations