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Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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TL;DR: Four new benzopyran- platinum (Pt) complexes were first designed and synthesized as mitochondria-targeting antitumor agents and showed cytotoxic activity against A549 and A549/DDP cancer cells, and most 6-chloro-substituted groups had stronger cytotoxicity than did the benzopryan Pt(II)-subst ituted ones.
3 citations
TL;DR: The configuration and conformation of all diastereoisomers were studied by combined NMR and computational analyses as discussed by the authors, and a preference for the conformer with both substituents in the pseudo-equatorial orientations was established.
Abstract: The configuration and conformation of cis/trans‐3,4‐dihydro‐2‐alkoxy‐4‐(alkyl‐ or aryl‐substituted)‐2H,5H‐pyrano[3,2‐c][1]benzopyran‐5‐one derivatives were studied by combined NMR and computational analyses. The cis/trans configurational assignments of all diastereoisomers were achieved via 2D NOESY experiments. The conformational analysis of cis compounds, performed via NMR and computational studies, allowed the establishment of a preference for the conformer with both substituents in the pseudo‐equatorial orientations. For trans derivatives only the molecular mechanics analysis produced meaningful results, suggesting a general prevalence for the conformer bearing the 2‐alkoxy group in a pseudo‐axial and the 4‐substituent in a pseudo‐equatorial orientation. © 1997 John Wiley & Sons, Ltd.
3 citations
3 citations
3 citations