Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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Patent•
28 May 1998
1 citations
1 citations
Patent•
22 Jun 1983TL;DR: In this article, the authors present a pharmaceutically acceptable salt of the benzopyran and benzothiopyran-4 -carboxylic acid aldose reductase inhibitors of the formula, with the proviso that at least one of the inhibitors is chloro, bromo or fluoro.
Abstract: of EP0011426Benzopyran- and benzothiopyran-4 -carboxylic acid aldose reductase inhibitors of the formula: or a pharmaceutically acceptable salt thereof, wherein x is 0, S, S = O or n is zero or one; R is hydrogen or alkyl of 1 to 4 carbon atoms; R1 is hydrogen, chloro, bromo, fluoro or phenyl; R2 and R3 when taken individually, are each hydrogen, alkyl of 1 to 3 carbon atoms, chloro, bromo or fluoro; and when taken together, R2, R3 and the carbon atoms to which they are connected form a fused benzene ring; with the proviso that at least one of R1, R2 and R3 is chloro, bromo or fluoro. The compounds are useful in the treatment of diabetic-associated complications, such as cataracts, neuropathy or retinopathy, in a diabetic host. Also disclosed are methods for preparing the compounds of the formula (I) and their salts, and pharmaceutical compositions containing them.
1 citations
Patent•
11 Jun 2003
TL;DR: In this paper, a parallel synthesis of 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives is described.
Abstract: PURPOSE: Provided are 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives synthesized in higher yield by using parallel synthesis on the solid-phase. The synthesized derivatives inhibit lipid peroxidation. CONSTITUTION: 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives are characterized by the formula(5), wherein R1 and R2 are the same or different each other, and represent a C1-C10 alkyl group, a benzyl group or a substituted benzyl group, or a penethyl group; and R3 represents a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, a benzyl group or a substituted benzyl group, or a naphthylmethyl group; wherein the substituted benzyl group has 1-4 substituents selected from a halogen atom, a nitro group, C1-C10 alkyl group, C1-C10 alkoxy group and C1-C10 haloalkyl group.
1 citations