Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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Patent•
31 Aug 1976
TL;DR: For example, benzothiopyrano-benzopyranes and the sulfur analogs thereof are useful as medicinal agents as mentioned in this paper, and derivatives thereof including acid addition salts.
Abstract: Benzopyrano-benzopyranes and the sulfur analogs thereof, benzothiopyranobenzothiopyranes, useful as medicinal agents. Compositions of matter including 11H,12H-[1]benzopyrano[2,3-b][1]benzopyran-11,12-dione or 11H,12H-[1]benzothiopyrano[2,3-b][1]benzothiopyran-11,12-dione, and derivatives thereof including acid addition salts.
Patent•
19 Nov 2020
TL;DR: In this article, a series of derivatives of a novel CDK9 inhibitor having a benzopyran structure and use thereof is presented. But the present invention relates to the field of biomedicine.
Abstract: The present invention relates to the field of biomedicine, and specifically comprises a series of derivatives of a novel CDK9 inhibitor having a benzopyran structure and use thereof. In view of the disadvantages of low anti-tumor activity and poor druggability of wogonin, the present invention modifies the mother nucleus thereof to synthesize a series of compounds, especially introduces N-containing cyclic substituents at the 3- or 4-position. These compounds are all novel, and have not been reported in the literature. At the same time, the inventors carried out a series of biological activity evaluation on the synthesized compounds. In particular, most of the compounds of the present invention have good selectivity for CDK9, and have better inhibitory activity against cancer cells.
Patent•
01 May 1996
TL;DR: In this paper, a new benzopyrans and other fused benzo-rings which are antagonists of leucotriene B4 corresponding to formula I where R1 is a phenyl or substituted phenyl group and A, n, R2 and R3 are as defined in the description.
Abstract: Benzopyran antagonists to leucotriene B4. This invention relates to: New benzopyrans and other fused benzo-rings which are antagonists of leucotriene B4 corresponding to formula I where R1 is a phenyl or substituted phenyl group and A, n, R2 and R3 are as defined in the description. Useful in the treatment of industrial diseases due to leucotriene B4.
TL;DR: In this article, the deformylative Mannich-type reaction was shown to be less reactive than the N-aryl analogues towards the deformation of Mannich reaction with sarcosine, piperidine, or diethylamine.
Abstract: 2-(Arylamino)-4-oxo-4H-chromene-3-carbaldehyde 3 (R2 = aryl) produces 12H-chromeno[2,3-b]quinolin-12-one 4 when treated with sarcosine, piperidine or diethylamine, but produces 3,3′-methylenebis(2-arylamino-4H-chromen-4-one) 8 when treated with the same amine in the presence of an excess of formaldehyde. Compound 3 (R2 = alkyl) was found to be less reactive than the N-aryl analogues towards the deformylative Mannich-type reaction.