Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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TL;DR: In this paper, the stereochemical correlations including the configurations of the ring juncture and the methyl group and also the ring conformations of these six lactones were investigated by chemical means and by nuclear magnetic resonance (NMR) spectrometry, such as two-dimensional(2D) NMR and steady-state 1H-1H nuclear Overhauser effect experiments.
Abstract: Four stereoisomers of 3-methyloctahydroisocoumarins (4a-d)and two 1-methyloctahydro-3H-2-benzopyran-3-ones (10a, b) were synthesized. The stereochemical correlations including the configurations of the ring juncture and the methyl group and also the ring conformations of these six lactones were investigated by chemical means and by nuclear magnetic resonance (NMR) spectrometry, such as two-dimensional(2D) NMR and steady-state 1H-1H nuclear Overhauser effect experiments. It was concluded that the lactone ring of 4b, c, and 10a adopts a boat or a slightly distorted boat conformation in solution.
Patent•
17 Jul 2014
TL;DR: A benzopyran derivative represented by general formula, or a salt thereof, is useful in therapeutic or preventive treatment of disease as discussed by the authors, wherein said therapeutic and preventive treatment is effective because the benopyrin derivative, or salt, binds to MIF, has an MIF inhibitory effect, and inhibits MIF.
Abstract: A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative, or salt thereof, binds to MIF, has an MIF inhibitory effect, and inhibits MIF. [In the formula, R1 represents an optionally substituted C1-6 alkyl group, one of R2 and R3 represents a hydrogen atom, and the other of R2 and R3 represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group, or an optionally substituted aryl group.]
TL;DR: The title compound was synthesized by microwave assisted method and characterized by X-ray diffraction method as discussed by the authors, it crystallizes in monoclinic space group P21/c with cell parameters a = 7.916(1)A, b = 15.736(2)A and c = 8.737(8)A.
Abstract: The title compound was synthesized by microwave-assisted method and characterized by X-ray diffraction method. It crystallizes in monoclinic space group P21/c with cell parameters a = 7.916(1)A, b = 15.736(2)A, c = 8.737(8)A, β = 108.11(6)°, Z = 4. The structure has C-H···O type hydrogen bonds.
Patent•
15 Apr 1992
TL;DR: In this paper, a new compound exhibiting durable hypotensive action and peripheral vessel relaxing action by the activation of calcium channel and useful as an agent for the treatment of hypertension was proposed.
Abstract: PURPOSE:To provide a new compound exhibiting durable hypotensive action and peripheral vessel relaxing action by the activation of calcium channel and useful as an agent for the treatment of hypertension CONSTITUTION:The compound of formula I (R is lower alkyl, cycloalkyl, etc; R is OH, lower alkoxy, etc; R is H or lower alkyl; R is H, OH, etc; R is lower alkyl, lower alkoxy, etc; R and R are lower alkyl or together form an alkylene), eg N-(trans-6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1- benzopyran-4-yl)-N'-hydroxyacetamidine The compound of formula I can be produced by reacting a compound of formula II (R is H, OH, etc) with a compound of formula III (X is alkoxy or alkylthio) and reacting the resultant compound of formula IV with a reagent (eg cyanogen bromide, ethyl chloroformate and isocyanate)
TL;DR: In this paper, synthesis and vasorelaxant activity of 2-fluoroalkyl-6-nitro-2H-1-benzopyran-4-carbothioamides4 and 6 and -carboxamides 5 and 7 are described.
Abstract: Synthesis and vasorelaxant activity of 2-fluoroalkyl-6-nitro-2H-1-benzopyran-4-carbothioamides4 and 6 and -carboxamides 5 and 7 are described. Potent smooth muscle relaxant activity was displayed by 6c.