Benzopyran

About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.

Studies on Sulfoxide Rearrangements: Regioselective Synthesis of 3-(Aryloxyacetyl)-2,3-dihydrothieno[3,2-c][1]benzopyran-4-ones.

Abstract: Hitherto unreported 3-(aryloxyacetyl)-2,3-dihydrothieno[3,2- c ][1] benzopyran-4-ones 5a – f were synthesised in 70–75% yields by the application of the sulfoxide rearrangement of 4-(4-aryloxybut-2-ynylthio)[1]benzopyran-2-ones 4a – f . The substrates 4a – f were synthesised by phase-transfer-catalysed alkylation of previously unreported 4-mercaptocoumarin.

New N-hydroxyalkyl-6-hydroxy-2-alkyl-2H-1-benzopyran-2-carboxamide derivatives useful for preparing cosmetic or pharmaceutical products for preventing biological damage caused by free radicals

Abstract: N-hydroxyalkyl-6-hydroxy-2-alkyl-2H-1-benzopyran-2-carboxamide derivatives (II) are new. N-hydroxyalkyl-6-hydroxy-2-alkyl-2H-1-benzopyran-2-carboxamide derivatives of formula (II) are new. R51-4C alkyl; R6-R8H, OH or 1-4C alkyl; and R : 2-30C alkyl. An independent claim is also included for preparing (I). [Image] ACTIVITY : Nootropic; Dermatological; Neuroprotective; Cytostatic; Cardiovascular-Gen. MECHANISM OF ACTION : Radical scavenger. N-(1-hydroxy-2-dodecyl)-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxamide reduced UV absorption (517 nm) of a 100 mu M diphenylpicrylhydrazide radical solution by 65% at a concentration of 20 mu M, compared with 71% for methyl gallate and 70% for N-(1-hydroxy-2-dodecyl)-3,4,5-trihydroxybenzamide and 91% for 6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid.

Method for preparing benzopyran compound and uses in protecting against pulmonary fibrosis

Abstract: Disclosed are a method for preparing a benzopyran compound and uses in protecting against pulmonary fibrosis. The structural formula of the benzopyran compound is shown by formula (I), R1 being one selected from hydrogen, C1-C4 alkyl and residual groups of various amino acids after removing amino parts, R2 being one selected from hydrogen, C1-C4 alkyl and residual groups of various amino acids after removing amino parts, R3 being one selected from hydrogen, C1-C4 alkyl and residual groups of various amino acids after removing amino parts, and n being any integer of 1 to 4. The benzopyran compound is obtained from a fermentation liquid of Streptomyces xiamenensis (CGMCC No.5675) by extraction, separation and purification. The Streptomyces xiamenensis extract derivative prepared in the present invention has higher performance of inhibiting the proliferation and activity of health human lung fibroblasts, and can be used for preparing anti-pulmonary fibrosis drugs.

Catalytic Asymmetric Intramolecular Cascade Reaction for the Construction of Functionalized Benzobicyclo[4.3.0] Skeletons. Remote Control of Enantioselectivity.

Abstract: Cyclopenta-fused benzopyran and naphthalene derivatives are prepared using a spirobiindane-based chiral phosphine as catalyst.