Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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TL;DR: In this paper, the pyranopyridine ring of 4-imidazol-2-ylmethyl)-4-chloroanilino-4-benzopyran was replaced with pyrnopyridines.
Abstract: We attempted to replace a benzopyran ring of 4-[(N-imidazol-2-ylmethyl)-4-chloroanilino]benzopyran, previously discovered as anti-angiogenic agent with antitumor activity, with pyranopyridines. The [3,2-c]-, [3,2-b]-, [2,3-c]-, and [2,3-b]-pyranopyridines with -(imidazol-2-ylmethyl)aniline moiety at the 4-position, were synthesized respectively, and evaluated for primary anti-angiogenic properties through primary cultured HUVEC tube formation assay. From this study, we found that the pyranopyridine ring, especially [3,2-b]- and [2,3-c]-isomer, can replace the benzopyran ring of the compound 1 and can be optimized through the introduction of substituents both on the pyranopyridine ring and the aniline moiety for the identification of a novel anti-angiogenic agent.
24 citations
TL;DR: To investigate the effects of configuration on bioactivity, spirooliganones A and B and their six diastereoisomers (1-8) were synthesized in 11 steps and the primary structure-activity relationships were analyzed.
24 citations
TL;DR: From the leaves of Mallotus apelta, seven benzopyran compounds were obtained and their structures were determined using spectroscopic methods and one showed moderate antibiotic activity against Micrococcus lutens.
24 citations
TL;DR: In this paper, the root of Beilschmiedia erythrophloia was identified and structural elucidation of two endiandric acid analogs, I and J (1 and 2, resp.).
Abstract: Phytochemical investigation of the root of Beilschmiedia erythrophloia led to the isolation and structural elucidation of two new endiandric acid analogs, endiandric acids I and J (1 and 2, resp.), a new benzopyran, dehydrooligandrol methyl ether (3), and a new benzenoid, farnesylol (4), together with six known compounds. Their structures were established on the basis of extensive 1D- and 2D-NMR analyses in combination with HR-MS experiments.
24 citations
TL;DR: In this paper, 2-C -acetoxymethyl glycal derivatives react with aliphatic alcohols in the presence of InCl 3 to furnish the corresponding 2-c -methylene glycosides in excellent yields and with exclusive α-selectivity.
24 citations