Topic
Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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TL;DR: A novel photoswitchable benzopyran-based ω-amino acid 6 for Fmoc-based solid-phase peptide synthesis is presented and the photochromic behaviour of the 3-cyano-substituted benzopyrs 5a was investigated by time-resolved absorption spectroscopy in the picosecond time domain.
Abstract: Photochromic pyrans for applications in material and life sciences were synthesized via palladium-mediated cyanation, carbonylation and Sonogashira cross-coupling starting from bromo-substituted naphthopyran 1 and benzopyrans 2a/b. A novel photoswitchable benzopyran-based ω-amino acid 6 for Fmoc-based solid-phase peptide synthesis is presented. The photochromic behaviour of the 3-cyano-substituted benzopyran 5a was investigated by time-resolved absorption spectroscopy in the picosecond time domain.
16 citations
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13 Oct 1992TL;DR: In this paper, the benzo-fused leukotriene B4 antagonists have formula (I) wherein A, n, R?1, R2 and R3? are as defined herein.
Abstract: Benzopyran and other benzo-fused leukotriene B4 antagonists have formula (I) wherein A, n, R?1, R2 and R3? are as defined herein. The compounds of formula (I) wherein R1 is c-substituted CR?4R5-COOR13? may be prepared from the corresponding c-substituted CF?3?SO3 compound by reaction with a trimethylsilyl ketene acetal.
16 citations
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26 May 1992
TL;DR: In this paper, the authors described the compositions and methods of use of benzopyranone and benzothiopyrinone compounds with adrenergic and serotonergic activity.
Abstract: The invention relates to benzopyranone and benzothiopyranone compounds, compositions and methods of use which have adrenergic and serotonergic activity.
16 citations
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TL;DR: A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol and introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyrans analogues 11 and 12.
Abstract: A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol. Polymer-bound 6-alkylaminobenzopyrans 7 were synthesized as part of a first generation diversification step by employing reactions of a variety of alkyl halides with the amine 6. Transformations of the resin-bound intermediates 8 formed in this manner by reactions with acid halides, sulfonyl chlorides, and isocyanates leads to introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyran analogues 11 and 12.
16 citations
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17 May 1989
TL;DR: In this article, the derivatives of the benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided, and the compounds possess vasodilating activity and are useful in the treatment of hypertension.
Abstract: Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension. Pharmaceutical compositions and methods of treating hypertension are also provided.
16 citations