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Benzopyran
About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.
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Patent•
30 Apr 2007
TL;DR: In this article, the field of aryl hydrocarbon receptor (Ah receptor; AhR) antagonists has been studied and a compound of formula (lII) or (V) in which R1 to R10 independently of one another can be hydrogen, hydroxyl, C1-C10-alkyl, and R5 can be replaced by a double bond as a drug, which is intended for reducing or preventing a translocation of the AhR into a cell nucleus.
Abstract: The invention relates to the field of aryl hydrocarbon receptor (Ah receptor; AhR) antagonists and to a compound of formula (lII) or (V) in which R1 to R10 independently of one another can be hydrogen, hydroxyl, C1-C10-alkyl, C1-C10-alkenyl, C1-C10-alkoxy, prenyl or O-glycosyl, and two radicals R1 to R10 can be joined via a methylenedioxy group -O-CH2-O-, and R5 can be replaced by a double bond, as a drug, which is intended for (a) reducing or preventing a translocation of the AhR into a cell nucleus, (b) reducing or preventing a UVB-induced or UVB-inducible gene expression, (c) reducing or preventing a gene expression induced or inducible by polycyclic aromatic hydrocarbons, preferably TCDD, and/or (d) reducing or preventing UVB-induced or UVB-inducible skin damage, especially skin cancer, skin ageing, skin inflammations and sunburn; as well as to process for the preparation of a drug, comprising the extraction of wood.
15 citations
TL;DR: Gold-catalyzed benzopyran formation and subsequent aryne reactions enabled us to prepare a wide range of benzopiran derivatives by virtue of their good functional group tolerance and versatile transformability of arynes intermediates.
15 citations
15 citations
TL;DR: N-Cyano-2,2-dimethyl-6-nitro-2H-1-benzopyran-4-carboxamidines have been synthesized.
15 citations
TL;DR: In this article, the X-ray crystal structure of 3-amino-2-cyano-3-(2-imino-4-methyl-2H-1-benzopyran-3-yl)prop 2-enoate has been determined, showing the presence of two molecules in the asymmetric unit.
Abstract: 2-Imino-4-methyl-2H-1-benzopyran-3-carbonitrile undergoes [1,5] tautomerism in solution to 2-amino-4-methylidene-4H-1-benzopyran-3-carbonitrile. Reaction with one equivalent of compounds containing a reactive methylene group affords simple 4-methylbenzopyran derivatives, and a methylidene derivative (of [1]benzopyrano[2,3-b][1,8]naphthyridine). Reaction with two and three equivalents of malononitrile affords derivatives of [1]benzopyrano[2,3,4-de]quinoline and [1]benzopyrano[2,3,4-de][1,6]-naphthyridine, which had previously been formulated as bicyclic benzopyran derivatives. The X-ray crystal structure of ethyl 3-amino-2-cyano-3-(2-imino-4-methyl-2H-1-benzopyran-3-yl)prop-2-enoate has been determined, showing the presence of two molecules in the asymmetric unit.
15 citations