Benzopyran

About: Benzopyran is a research topic. Over the lifetime, 1889 publications have been published within this topic receiving 15235 citations.

Synthesis of some thiadiazoles, selenadiazoles and spiroheterocyclic compounds from their 2,2-dimethyl-benzopyran precursors

Abstract: New series of 4,4-dimethylbenzopyrano[4,3-d]-1,2,3-selenadiazoles and 4,4-dimethylbenzopyrano-[4,3-d]-1,2,3-thiadiazoles have been synthesized from semicarbazones of chroman-4-one precursors. Some 4-acetyl-2′-acetylamino-2,2-dimethylspiro[chroman-4,5′-2-1,3,4-thiadiazolines] have been synthesized by cyclization of thiosemicarbazones of 2,2-dimethylchroman-4-ones using acetic anhydride. The selected compounds were tested for Phosphotyrosine phosphatase 1B inhibition.

Stereoselective acetylation of 3,4-dihydro-3,4-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Abstract: The chiral intermediate diol (3 S ,4 R )-trans-3,4-dihydro-3,4-dihydroxy-2,2-dimethyl-2 H -1-benzopyran-6-carbonitrile 2 . was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic 1 was carried out with various lipases among which the lipases from Candida cylindraceae and Pseudomonas cepacia catalyzed the acetylation of the undesired enantiomer of racemic 1 to yield monoacetylated product and unreacted desired (+)-trans diol 2 . A reaction yield of >40% and an optical purity >90% were obtained using each lipase.