Topic
Benzopyrans
About: Benzopyrans is a research topic. Over the lifetime, 694 publications have been published within this topic receiving 8830 citations.
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TL;DR: The title aldehyde 1 in the presence of ammonia gives the pyridine derivatives 9-11 respectively with acetylacetone, diethyl malonate and ethyl cyanoacetate, and the coumarinopyridines 25 and 26, respectively as discussed by the authors.
39 citations
Patent•
22 Oct 1992TL;DR: In this paper, the authors provided compounds of formula "STR1" where R1 and R2 are each --H, --OH, alkoxy of 1 to 17 carbon atoms or alkoxy carbonyl of 2 to 18 carbon atoms and R3 is ##STR2## are useful in the treatment of an estrogen dependent condition such as breast cancer.
Abstract: The present invention provides compounds of formula ##STR1## wherein R1 and R2, which may be the same or different, are each --H, --OH, alkoxy of 1 to 17 carbon atoms or alkoxycarbonyl of 2 to 18 carbon atoms and R3 is ##STR2## are useful in the treatment of an estrogen dependent condition such as breast cancer.
38 citations
TL;DR: Modification of both positions proved additive, maintaining affinity and improving ERbeta selectivity up to 83-fold, and confirming the previously observed binding mode in ERbeta.
38 citations
TL;DR: Les substitutions nucleophiles des chromannes du titre avec le [cyano trimethyl] silane sont etudiees as discussed by the authors, and le catalyseur, TiCl 4 ou SnCl 4, a une influence sur la regioselectivite des reactions
Abstract: Les substitutions nucleophiles des chromannes du titre avec le [cyano trimethyl] silane sont etudiees. Le catalyseur, TiCl 4 ou SnCl 4 , a une influence sur la regioselectivite des reactions
38 citations
TL;DR: The catalytic addition of the amino acid derived bifunctional N-acylaminophosphine to an α-substituted allene ester generated a zwitterionic dipole to deliver tetrahydroxanthones embodying three consecutive chiral centers in high yields and with excellent enantioselectivities.
37 citations