Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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684 citations
TL;DR: A series of macrocyclic receptors designed to probe the influence of four factors, hydrogen bonding, charge, dimensionality, and topology, on anion binding indicate a number of corollaries with transition-metal coordination chemistry in terms of binding concepts such as the chelate effect and dual valencies.
Abstract: A series of macrocyclic receptors were designed to probe the influence of four factors, hydrogen bonding, charge, dimensionality, and topology, on anion binding. Monocyclic and bicyclic polyammonium and polyamide receptors were synthesized from either 2,2‘-diaminodiethylamine derivatives (dien) or 2,2‘,2‘ ‘-aminoethylamine (tren) building blocks, plus aromatic or heterocyclic spacers. Supramolecular complexes of these hosts with three simple anion topologies were probed: spherical (halides), trigonal planar (nitrate), and tetrahedral (sulfate). Results indicate a number of corollaries with transition-metal coordination chemistry in terms of binding concepts such as the chelate effect and dual valencies, as well as geometries for anion complexes that are strikingly similar to those observed in transition-metal coordination chemistry.
627 citations
TL;DR: PyBOP as discussed by the authors, an analog of BOP where dimethylamino groups are replaced with pyrrolidino, is the only analog exhibiting equivalent properties in peptide bond formation.
596 citations