Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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TL;DR: A new, efficient, diastereoselective tandem intramolecular hetero-[5+2] cycloaddition/Claisen rearrangement of vinylic oxirane-alkyne substrates that uses a rhodium NHC complex and provides strategically novel, atom-economic, regiospecific, and diastsereoselected access to [3.1.0] bicyclic products has been developed.
Abstract: The first synthetic application of a vinylic oxirane as a heteroatom-containing five-atom component in transition-metal-catalyzed cycloaddition reactions is reported. A new, efficient, diastereoselective tandem intramolecular hetero-[5 + 2] cycloaddition/Claisen rearrangement of vinylic oxirane-alkyne substrates that uses a rhodium NHC complex and provides strategically novel, atom-economic, regiospecific, and diastereoselective access to [3.1.0] bicyclic products has been developed.
85 citations
TL;DR: In this paper, the authors proposed a method for the heterocyclization of acetylenic alcohols or acids, which provides an easy and mild access to α-methylene oxygenated heterocycles.
85 citations
85 citations
TL;DR: In this article, a general protocol for the synthesis of α-amino-α- alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from ( R,R )- and ( S,S )-1,2-diaminocyclohexane.
85 citations
TL;DR: In this article, the palladium-catalysed preparation of some heterocondensed pyrroles from ortho nitrogen containing hetaryl iodides and derivatives of propargyl alcohol is described.
85 citations